Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management
Background: Designated as a “priority disease” by World Health Organization, Osteoarthritis is the most common chronic rheumatic disease. Providing a proper treatment for Osteoarthritis is still a major public health challenge. Diacerein has been proposed as a slow acting, symptom modifying or even...
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| Format: | Article |
| Language: | English |
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Nepal Health Research Council
2023-07-01
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| Series: | Journal of Nepal Health Research Council |
| Online Access: | https://jnhrc.com.np/index.php/jnhrc/article/view/4323 |
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| author | Rohit Shrestha Sudichhya Tamrakar Pramesh Koju Sagar Maharjan Subhechhya Malla Sony Shakya Shrestha |
| author_facet | Rohit Shrestha Sudichhya Tamrakar Pramesh Koju Sagar Maharjan Subhechhya Malla Sony Shakya Shrestha |
| author_sort | Rohit Shrestha |
| collection | DOAJ |
| description |
Background: Designated as a “priority disease” by World Health Organization, Osteoarthritis is the most common chronic rheumatic disease. Providing a proper treatment for Osteoarthritis is still a major public health challenge. Diacerein has been proposed as a slow acting, symptom modifying or even disease modifying drug used in Osteoarthritis having a risk-benefit ratio far better than conventionally used drugs. However, the evidence of efficacy and safety of use of Diacerein in Osteoarthritis is yet to be explored. Hence, this study attempted to investigate the efficacy and safety of Diacerein in the management of knee osteoarthritis.
Methods: This is an analytical cohort study comparing Diacerein with Non-steroidal anti-inflammatory drugs for two months in the management of knee OA. Efficacy was assessed by scores of Lysholm Knee Scoring Scale, Knee injury and Osteoarthritis Outcome Score – Physical Function Short form and Western Ontario and McMaster Universities Osteoarthritis Index.
Results: After two months of treatment, the post- treatment scores were significantly superior to the baseline scores in both the treatment groups (p<0.001). There were no significant differences among the post-treatment scores in two different treatment groups (p>0.05). Discoloration of urine and gastritis were the frequently reported adverse effects in Diacerein treatment group and Non-steroidal anti-inflammatory drugs treatment group respectively.
Conclusions: Our findings have shown Diacerein is as effective as Non-steroidal anti-inflammatory drugs in treating knee OA patients. Diacerein was generally well tolerated, with a good safety profile. These findings indicate the need for further studies with experimental study design in larger scale.
Keywords: Diacerein; Efficacy; Knee Osteoarthritis; NSAIDs; Safety
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| first_indexed | 2024-03-12T22:45:17Z |
| format | Article |
| id | doaj.art-8184c4c64aad4c1ab78efa59bb850c76 |
| institution | Directory Open Access Journal |
| issn | 1727-5482 1999-6217 |
| language | English |
| last_indexed | 2024-03-12T22:45:17Z |
| publishDate | 2023-07-01 |
| publisher | Nepal Health Research Council |
| record_format | Article |
| series | Journal of Nepal Health Research Council |
| spelling | doaj.art-8184c4c64aad4c1ab78efa59bb850c762023-07-21T06:25:49ZengNepal Health Research CouncilJournal of Nepal Health Research Council1727-54821999-62172023-07-0120410.33314/jnhrc.v20i4.4323Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional managementRohit Shrestha0Sudichhya Tamrakar1Pramesh Koju2Sagar Maharjan3Subhechhya Malla4Sony Shakya Shrestha5Department of Orthopedics, Dhulikhel Hospital- Kathmandu University HospitalResearch and Development Division, Dhulikhel Hospital, Dhulikhel, NepalPharmacovigilance Unit, Dhulikhel Hospital, Dhulikhel, NepalDepartment of Orthopedics, Dhulikhel Hospital- Kathmandu University HospitalDepartment of Physiotherapy, Dhulikhel Hospital- Kathmandu University HospitalDepartment of Pharmacology, Kathmandu University School of Medical Sciences, Kathmandu University, Dhulikhel, Nepal Background: Designated as a “priority disease” by World Health Organization, Osteoarthritis is the most common chronic rheumatic disease. Providing a proper treatment for Osteoarthritis is still a major public health challenge. Diacerein has been proposed as a slow acting, symptom modifying or even disease modifying drug used in Osteoarthritis having a risk-benefit ratio far better than conventionally used drugs. However, the evidence of efficacy and safety of use of Diacerein in Osteoarthritis is yet to be explored. Hence, this study attempted to investigate the efficacy and safety of Diacerein in the management of knee osteoarthritis. Methods: This is an analytical cohort study comparing Diacerein with Non-steroidal anti-inflammatory drugs for two months in the management of knee OA. Efficacy was assessed by scores of Lysholm Knee Scoring Scale, Knee injury and Osteoarthritis Outcome Score – Physical Function Short form and Western Ontario and McMaster Universities Osteoarthritis Index. Results: After two months of treatment, the post- treatment scores were significantly superior to the baseline scores in both the treatment groups (p<0.001). There were no significant differences among the post-treatment scores in two different treatment groups (p>0.05). Discoloration of urine and gastritis were the frequently reported adverse effects in Diacerein treatment group and Non-steroidal anti-inflammatory drugs treatment group respectively. Conclusions: Our findings have shown Diacerein is as effective as Non-steroidal anti-inflammatory drugs in treating knee OA patients. Diacerein was generally well tolerated, with a good safety profile. These findings indicate the need for further studies with experimental study design in larger scale. Keywords: Diacerein; Efficacy; Knee Osteoarthritis; NSAIDs; Safety https://jnhrc.com.np/index.php/jnhrc/article/view/4323 |
| spellingShingle | Rohit Shrestha Sudichhya Tamrakar Pramesh Koju Sagar Maharjan Subhechhya Malla Sony Shakya Shrestha Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management Journal of Nepal Health Research Council |
| title | Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management |
| title_full | Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management |
| title_fullStr | Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management |
| title_full_unstemmed | Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management |
| title_short | Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management |
| title_sort | investigating the efficacy and safety of diacerein in the management of knee osteoarthritis with reference to its conventional management |
| url | https://jnhrc.com.np/index.php/jnhrc/article/view/4323 |
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