The Trinity: Interplay among Cancer Cells, Fibroblasts, and Immune Cells in Pancreatic Cancer and Implication of CD8<sup>+</sup> T Cell-Orientated Therapy

The Trinity: Interplay among Cancer Cells, Fibroblasts, and Immune Cells in Pancreatic Cancer and Implication of CD8<sup>+</sup> T Cell-Orientated Therapy

The microenvironment in tumors is complicated and is constituted by different cell types and stromal proteins. Among the cell types, the abundance of cancer cells, fibroblasts, and immune cells is high and these cells work as the “Trinity” in promoting tumorigenesis. Although unidirectional or bidir...

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Bibliographic Details
Main Authors: Yu-Hsuan Hung, Li-Tzong Chen, Wen-Chun Hung
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
pancreatic cancer
fibroblasts
immunity
CD8<sup>+</sup> T cells
Online Access:https://www.mdpi.com/2227-9059/10/4/926

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