Impact of Clonal Architecture on Clinical Course and Prognosis in Patients With Myeloproliferative Neoplasms

Impact of Clonal Architecture on Clinical Course and Prognosis in Patients With Myeloproliferative Neoplasms

Myeloproliferative neoplasms (MPNs) are caused by a somatic gain-of-function mutation in 1 of the 3 disease driver genes JAK2, MPL, or CALR. About half of the MPNs patients also carry additional somatic mutations that modify the clinical course. The order of acquisition of these gene mutations has b...

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Bibliographic Details
Main Authors: Damien Luque Paz, Michael S. Bader, Ronny Nienhold, Shivam Rai, Tiago Almeida Fonseca, Jan Stetka, Hui Hao-Shen, Gabriele Mild-Schneider, Jakob R. Passweg, Radek C. Skoda
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000885

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