Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc.
The purpose of this study was to develop a method of quantifying the degree of optic disc tilt in normal eyes. This was a prospective, observational cross sectional study of 126 right eyes of 126 healthy volunteers. The optic disc tilt was determined from the circular peripapillary optical coherence...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4388545?pdf=render |
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| author | Takehiro Yamashita Taiji Sakamoto Naoya Yoshihara Hiroto Terasaki Yuya Kii Minoru Tanaka Kumiko Nakao |
| author_facet | Takehiro Yamashita Taiji Sakamoto Naoya Yoshihara Hiroto Terasaki Yuya Kii Minoru Tanaka Kumiko Nakao |
| author_sort | Takehiro Yamashita |
| collection | DOAJ |
| description | The purpose of this study was to develop a method of quantifying the degree of optic disc tilt in normal eyes. This was a prospective, observational cross sectional study of 126 right eyes of 126 healthy volunteers. The optic disc tilt was determined from the circular peripapillary optical coherence tomographic (OCT) scan images. The course of the retinal pigment epithelium (RPE) layer in the peripapillary cross sectional scan images was fit to a sine wave curve, and the amplitude of the sine curve was used to reflect the degree of the optic disc tilt in the optical axis. The repeatability of the amplitude determinations was calculated. The correlation between the amplitude and the ovality ratio of the optic disc was determined. The correlation between the amplitude and the body height was also calculated. The mean amplitude was 36.6 ± 17.5 pixels, which was significantly and inversely correlated with the ovality ratio of the optic disc (R = -0.59, P < 0.001). The intra-rater and inter-rater correlation coefficients of the amplitude were significant high (P < 0.001, both). The amplitude was significantly and inversely correlated with the body height (R = -0.38, P < 0.001), but not with the axial length. In conclusion, a sine wave function can be used to describe the course of the RPE in the circumpapillary OCT images. The results indicate that the amplitude of the sine wave can be used to represent the degree of optic disc tilt. Thus, the sine wave analyses can be used as a quantifiable and repeatable method to determine the optic disc tilt. |
| first_indexed | 2024-12-13T19:54:57Z |
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| id | doaj.art-8186d10f996549c59aea4f8585b13a9c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T19:54:57Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-8186d10f996549c59aea4f8585b13a9c2022-12-21T23:33:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012219110.1371/journal.pone.0122191Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc.Takehiro YamashitaTaiji SakamotoNaoya YoshiharaHiroto TerasakiYuya KiiMinoru TanakaKumiko NakaoThe purpose of this study was to develop a method of quantifying the degree of optic disc tilt in normal eyes. This was a prospective, observational cross sectional study of 126 right eyes of 126 healthy volunteers. The optic disc tilt was determined from the circular peripapillary optical coherence tomographic (OCT) scan images. The course of the retinal pigment epithelium (RPE) layer in the peripapillary cross sectional scan images was fit to a sine wave curve, and the amplitude of the sine curve was used to reflect the degree of the optic disc tilt in the optical axis. The repeatability of the amplitude determinations was calculated. The correlation between the amplitude and the ovality ratio of the optic disc was determined. The correlation between the amplitude and the body height was also calculated. The mean amplitude was 36.6 ± 17.5 pixels, which was significantly and inversely correlated with the ovality ratio of the optic disc (R = -0.59, P < 0.001). The intra-rater and inter-rater correlation coefficients of the amplitude were significant high (P < 0.001, both). The amplitude was significantly and inversely correlated with the body height (R = -0.38, P < 0.001), but not with the axial length. In conclusion, a sine wave function can be used to describe the course of the RPE in the circumpapillary OCT images. The results indicate that the amplitude of the sine wave can be used to represent the degree of optic disc tilt. Thus, the sine wave analyses can be used as a quantifiable and repeatable method to determine the optic disc tilt.http://europepmc.org/articles/PMC4388545?pdf=render |
| spellingShingle | Takehiro Yamashita Taiji Sakamoto Naoya Yoshihara Hiroto Terasaki Yuya Kii Minoru Tanaka Kumiko Nakao Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc. PLoS ONE |
| title | Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc. |
| title_full | Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc. |
| title_fullStr | Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc. |
| title_full_unstemmed | Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc. |
| title_short | Circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc. |
| title_sort | circumpapillary course of retinal pigment epithelium can be fit to sine wave and amplitude of sine wave is significantly correlated with ovality ratio of optic disc |
| url | http://europepmc.org/articles/PMC4388545?pdf=render |
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