Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis
ABSTRACT Objective: To determine the demographic and clinical characteristics of patients with non-small cell lung cancer (NSCLC), as well as their disease course, by age group and gender. Methods: This was a retrospective cohort study of patients diagnosed with NSCLC from 2000 to 2012 and followe...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pneumologia e Tisiologia
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| Series: | Jornal Brasileiro de Pneumologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000600431&lng=en&tlng=en |
| _version_ | 1818893073828020224 |
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| author | Juliana Pereira Franceschini Sérgio Jamnik Ilka Lopes Santoro |
| author_facet | Juliana Pereira Franceschini Sérgio Jamnik Ilka Lopes Santoro |
| author_sort | Juliana Pereira Franceschini |
| collection | DOAJ |
| description | ABSTRACT Objective: To determine the demographic and clinical characteristics of patients with non-small cell lung cancer (NSCLC), as well as their disease course, by age group and gender. Methods: This was a retrospective cohort study of patients diagnosed with NSCLC from 2000 to 2012 and followed until July 2015 in a tertiary referral hospital in the city of São Paulo, Brazil. Based on the 25th and 75th percentiles of the age distribution, patients were stratified into three age groups: < 55 years; ≥ 55 and < 72 years; and ≥ 72 years. Survival time was evaluated during the follow-up period of the study. Functions of overall and gender-specific survival stratified by age groups (event: all-cause mortality) were calculated using the Kaplan-Meier method. Differences among survival curves were assessed via the log-rank test. Results: We included 790 patients with the following age distribution: < 55 years, 165 patients; ≥ 55 and < 72 years, 423; and ≥ 72 years, 202. In the entire sample, there were 493 men (62.4%). Adenocarcinoma was the most common histological pattern in the < 72-year age groups; 575 patients (73%) presented with advanced disease (stages IIIB-IV). The median 5-year survival was 12 months (95% CI: 4-46 months), with no significant differences among the age groups studied. Conclusions: NSCLC remains more common in men, although we found an increase in the proportion of the disease in women in the < 55-year age group. Adenocarcinoma predominated in women. In men, squamous cell carcinoma predominated in the ≥ 72-year age group. Most patients presented with advanced-stage disease at diagnosis. There were no statistical differences in survival between genders or among age groups. |
| first_indexed | 2024-12-19T18:06:48Z |
| format | Article |
| id | doaj.art-8186e36638e44e02a0a6937f7de14460 |
| institution | Directory Open Access Journal |
| issn | 1806-3756 |
| language | English |
| last_indexed | 2024-12-19T18:06:48Z |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj.art-8186e36638e44e02a0a6937f7de144602022-12-21T20:11:27ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-375643643143610.1590/s1806-37562016000000298S1806-37132017000600431Survival in a cohort of patients with lung cancer: the role of age and gender in prognosisJuliana Pereira FranceschiniSérgio JamnikIlka Lopes SantoroABSTRACT Objective: To determine the demographic and clinical characteristics of patients with non-small cell lung cancer (NSCLC), as well as their disease course, by age group and gender. Methods: This was a retrospective cohort study of patients diagnosed with NSCLC from 2000 to 2012 and followed until July 2015 in a tertiary referral hospital in the city of São Paulo, Brazil. Based on the 25th and 75th percentiles of the age distribution, patients were stratified into three age groups: < 55 years; ≥ 55 and < 72 years; and ≥ 72 years. Survival time was evaluated during the follow-up period of the study. Functions of overall and gender-specific survival stratified by age groups (event: all-cause mortality) were calculated using the Kaplan-Meier method. Differences among survival curves were assessed via the log-rank test. Results: We included 790 patients with the following age distribution: < 55 years, 165 patients; ≥ 55 and < 72 years, 423; and ≥ 72 years, 202. In the entire sample, there were 493 men (62.4%). Adenocarcinoma was the most common histological pattern in the < 72-year age groups; 575 patients (73%) presented with advanced disease (stages IIIB-IV). The median 5-year survival was 12 months (95% CI: 4-46 months), with no significant differences among the age groups studied. Conclusions: NSCLC remains more common in men, although we found an increase in the proportion of the disease in women in the < 55-year age group. Adenocarcinoma predominated in women. In men, squamous cell carcinoma predominated in the ≥ 72-year age group. Most patients presented with advanced-stage disease at diagnosis. There were no statistical differences in survival between genders or among age groups.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000600431&lng=en&tlng=enNeoplasias pulmonaresGrupos etáriosSexoSobrevivência |
| spellingShingle | Juliana Pereira Franceschini Sérgio Jamnik Ilka Lopes Santoro Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis Jornal Brasileiro de Pneumologia Neoplasias pulmonares Grupos etários Sexo Sobrevivência |
| title | Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis |
| title_full | Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis |
| title_fullStr | Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis |
| title_full_unstemmed | Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis |
| title_short | Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis |
| title_sort | survival in a cohort of patients with lung cancer the role of age and gender in prognosis |
| topic | Neoplasias pulmonares Grupos etários Sexo Sobrevivência |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132017000600431&lng=en&tlng=en |
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