SPONTANEOUS SUBUNGUAL HEMORRHAGES IN A PATIENT WITH METABOLIC SYNDROME AND HYPERHOMOCYSTEINEMIA: A CASE REPORT
Spontaneous (nontraumatic) subungual hemorrhages are not uncommon, however, given their low specificity, they usually do not become a reason for an in-depth investigation in the absence of other symptoms of diseases requiring diagnostics. However, it is generally accepted that the nail bed is one of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Scientia Publishing House
2020-07-01
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| Series: | Juvenis Scientia |
| Subjects: | |
| Online Access: | https://www.elibrary.ru/item.asp?id=43791201 |
| _version_ | 1819173017365774336 |
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| author | I. Yu. Pchelin N. V. Hudiakova |
| author_facet | I. Yu. Pchelin N. V. Hudiakova |
| author_sort | I. Yu. Pchelin |
| collection | DOAJ |
| description | Spontaneous (nontraumatic) subungual hemorrhages are not uncommon, however, given their low specificity, they usually do not become a reason for an in-depth investigation in the absence of other symptoms of diseases requiring diagnostics. However, it is generally accepted that the nail bed is one of the few areas of the human body available for life-time diagnostics of the state of microvessels and the process of microcirculation. In the presented clinical case, examination of a 38-year-old patient with spontaneous subungual hemorrhages on the toes revealed a number of metabolic disorders: hyperhomocysteinemia, lipid and carbohydrate metabolism disturbances. Genetic tests showed the presence of several single nucleotide polymorphisms in the genes of the folate cycle enzymes (MTHFR A1298C, MTRR A66G, MTR A2756G) in a heterozygous form. Based on the presented results of the patient's examination, the paper discusses the mechanisms and relevant clinical aspects of the relationship between hyperhomocysteinemia, disorders of carbohydrate metabolism, and microangiopathy. |
| first_indexed | 2024-12-22T20:16:23Z |
| format | Article |
| id | doaj.art-818773516da44c84b43bee13706bbb5f |
| institution | Directory Open Access Journal |
| issn | 2414-3782 2414-3790 |
| language | English |
| last_indexed | 2024-12-22T20:16:23Z |
| publishDate | 2020-07-01 |
| publisher | Scientia Publishing House |
| record_format | Article |
| series | Juvenis Scientia |
| spelling | doaj.art-818773516da44c84b43bee13706bbb5f2022-12-21T18:13:57ZengScientia Publishing HouseJuvenis Scientia2414-37822414-37902020-07-01634450SPONTANEOUS SUBUNGUAL HEMORRHAGES IN A PATIENT WITH METABOLIC SYNDROME AND HYPERHOMOCYSTEINEMIA: A CASE REPORTI. Yu. Pchelin0https://orcid.org/0000-0001-8529-3890N. V. Hudiakova1https://orcid.org/0000-0003-0187-0457Saint Petersburg State UniversitySaint Petersburg State UniversitySpontaneous (nontraumatic) subungual hemorrhages are not uncommon, however, given their low specificity, they usually do not become a reason for an in-depth investigation in the absence of other symptoms of diseases requiring diagnostics. However, it is generally accepted that the nail bed is one of the few areas of the human body available for life-time diagnostics of the state of microvessels and the process of microcirculation. In the presented clinical case, examination of a 38-year-old patient with spontaneous subungual hemorrhages on the toes revealed a number of metabolic disorders: hyperhomocysteinemia, lipid and carbohydrate metabolism disturbances. Genetic tests showed the presence of several single nucleotide polymorphisms in the genes of the folate cycle enzymes (MTHFR A1298C, MTRR A66G, MTR A2756G) in a heterozygous form. Based on the presented results of the patient's examination, the paper discusses the mechanisms and relevant clinical aspects of the relationship between hyperhomocysteinemia, disorders of carbohydrate metabolism, and microangiopathy.https://www.elibrary.ru/item.asp?id=43791201subungual hemorrhagesnail bedmicrocirculationmicrovesselshyperhomocysteinemiahomocysteinemetabolic syndromedifferential diagnosisclinical case |
| spellingShingle | I. Yu. Pchelin N. V. Hudiakova SPONTANEOUS SUBUNGUAL HEMORRHAGES IN A PATIENT WITH METABOLIC SYNDROME AND HYPERHOMOCYSTEINEMIA: A CASE REPORT Juvenis Scientia subungual hemorrhages nail bed microcirculation microvessels hyperhomocysteinemia homocysteine metabolic syndrome differential diagnosis clinical case |
| title | SPONTANEOUS SUBUNGUAL HEMORRHAGES IN A PATIENT WITH METABOLIC SYNDROME AND HYPERHOMOCYSTEINEMIA: A CASE REPORT |
| title_full | SPONTANEOUS SUBUNGUAL HEMORRHAGES IN A PATIENT WITH METABOLIC SYNDROME AND HYPERHOMOCYSTEINEMIA: A CASE REPORT |
| title_fullStr | SPONTANEOUS SUBUNGUAL HEMORRHAGES IN A PATIENT WITH METABOLIC SYNDROME AND HYPERHOMOCYSTEINEMIA: A CASE REPORT |
| title_full_unstemmed | SPONTANEOUS SUBUNGUAL HEMORRHAGES IN A PATIENT WITH METABOLIC SYNDROME AND HYPERHOMOCYSTEINEMIA: A CASE REPORT |
| title_short | SPONTANEOUS SUBUNGUAL HEMORRHAGES IN A PATIENT WITH METABOLIC SYNDROME AND HYPERHOMOCYSTEINEMIA: A CASE REPORT |
| title_sort | spontaneous subungual hemorrhages in a patient with metabolic syndrome and hyperhomocysteinemia a case report |
| topic | subungual hemorrhages nail bed microcirculation microvessels hyperhomocysteinemia homocysteine metabolic syndrome differential diagnosis clinical case |
| url | https://www.elibrary.ru/item.asp?id=43791201 |
| work_keys_str_mv | AT iyupchelin spontaneoussubungualhemorrhagesinapatientwithmetabolicsyndromeandhyperhomocysteinemiaacasereport AT nvhudiakova spontaneoussubungualhemorrhagesinapatientwithmetabolicsyndromeandhyperhomocysteinemiaacasereport |