Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma
Background: Head and neck squamous cell carcinoma’s tumor immune microenvironment (TIME) plays an important role in tumorigenesis and progression, but its clinical significance remains unclear. Therefore, the TIME needs to be better understood in order to improve the response of diagnosis and therap...
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Frontiers Media S.A.
2022-05-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.860712/full |
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| author | Kaixin Su Kaixin Su Kaixin Su Kaixin Su Kaixin Su Kaixin Su Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Qiao Yi Qiao Yi Qiao Yi Qiao Yi Qiao Yi Qiao Yi Junjie Liu Junjie Liu Junjie Liu Junjie Liu Junjie Liu Junjie Liu Tiao Luo Tiao Luo Tiao Luo Tiao Luo Tiao Luo Tiao Luo Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Haixia Zhang |
| author_facet | Kaixin Su Kaixin Su Kaixin Su Kaixin Su Kaixin Su Kaixin Su Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Qiao Yi Qiao Yi Qiao Yi Qiao Yi Qiao Yi Qiao Yi Junjie Liu Junjie Liu Junjie Liu Junjie Liu Junjie Liu Junjie Liu Tiao Luo Tiao Luo Tiao Luo Tiao Luo Tiao Luo Tiao Luo Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Haixia Zhang |
| author_sort | Kaixin Su |
| collection | DOAJ |
| description | Background: Head and neck squamous cell carcinoma’s tumor immune microenvironment (TIME) plays an important role in tumorigenesis and progression, but its clinical significance remains unclear. Therefore, the TIME needs to be better understood in order to improve the response of diagnosis and therapy.Methods: The gene expression and clinical data of 569 HNSCC patients were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). Immune-related genes (IRGs) from the ImmPort database were used for immunotyping of HNSCC patients, and independent GEO datasets were used for subtype verification and comprehensive molecular identification.Results: The patients were divided into three subtypes (C1, C2, and C3) related to different gene expression profiles. The three subtypes showed widely different patterns in tumor genetic distortion, immune cell composition, cytokine profile, and so on, verifying that the immune-enhanced C2 subtype was associated with better prognosis. In addition, the stroma-deficient C1 subtype may be more efficient for the immune response than the C3 subtype. Furthermore, using WGCNA on the IRGs of those three subtypes, we found two C2-positive gene modules closely related to infection- and immune-associated pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, and the two modules had 22 common pathways.Conclusion: This study improves the power for prognosis prediction and develops new therapeutic strategies to stratify HNSCC patients into clinically significant groups through TIME-related prognostic signature. |
| first_indexed | 2024-12-12T04:39:32Z |
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| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-12T04:39:32Z |
| publishDate | 2022-05-01 |
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| series | Frontiers in Genetics |
| spelling | doaj.art-818a3705ad9a4d39bac69b1fa4bbcf3a2022-12-22T00:37:51ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-05-011310.3389/fgene.2022.860712860712Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell CarcinomaKaixin Su0Kaixin Su1Kaixin Su2Kaixin Su3Kaixin Su4Kaixin Su5Zekun Zhou6Zekun Zhou7Zekun Zhou8Zekun Zhou9Zekun Zhou10Zekun Zhou11Qiao Yi12Qiao Yi13Qiao Yi14Qiao Yi15Qiao Yi16Qiao Yi17Junjie Liu18Junjie Liu19Junjie Liu20Junjie Liu21Junjie Liu22Junjie Liu23Tiao Luo24Tiao Luo25Tiao Luo26Tiao Luo27Tiao Luo28Tiao Luo29Xinyan Cui30Xinyan Cui31Xinyan Cui32Xinyan Cui33Xinyan Cui34Xinyan Cui35Haixia Zhang36Academician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Oral Health Research, Central South University, Changsha, ChinaHunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, ChinaHunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, ChinaXiangya Stomatological Hospital, Central South University, Changsha, ChinaXiangya School of Stomatology, Central South University, Changsha, ChinaAcademician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Oral Health Research, Central South University, Changsha, ChinaHunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, ChinaHunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, ChinaXiangya Stomatological Hospital, Central South University, Changsha, ChinaXiangya School of Stomatology, Central South University, Changsha, ChinaAcademician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Oral Health Research, Central South University, Changsha, ChinaHunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, ChinaHunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, ChinaXiangya Stomatological Hospital, Central South University, Changsha, ChinaXiangya School of Stomatology, Central South University, Changsha, ChinaAcademician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Oral Health Research, Central South University, Changsha, ChinaHunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, ChinaHunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, ChinaXiangya Stomatological Hospital, Central South University, Changsha, ChinaXiangya School of Stomatology, Central South University, Changsha, ChinaAcademician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Oral Health Research, Central South University, Changsha, ChinaHunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, ChinaHunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, ChinaXiangya Stomatological Hospital, Central South University, Changsha, ChinaXiangya School of Stomatology, Central South University, Changsha, ChinaAcademician Workstation for Oral-Maxilofacial and Regenerative Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Oral Health Research, Central South University, Changsha, ChinaHunan 3D Printing Engineering Research Center of Oral Care, Central South University, Changsha, ChinaHunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha, ChinaXiangya Stomatological Hospital, Central South University, Changsha, ChinaXiangya School of Stomatology, Central South University, Changsha, ChinaThe Oncology Department of Xiangya Second Hospital, Central South University, Changsha, ChinaBackground: Head and neck squamous cell carcinoma’s tumor immune microenvironment (TIME) plays an important role in tumorigenesis and progression, but its clinical significance remains unclear. Therefore, the TIME needs to be better understood in order to improve the response of diagnosis and therapy.Methods: The gene expression and clinical data of 569 HNSCC patients were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). Immune-related genes (IRGs) from the ImmPort database were used for immunotyping of HNSCC patients, and independent GEO datasets were used for subtype verification and comprehensive molecular identification.Results: The patients were divided into three subtypes (C1, C2, and C3) related to different gene expression profiles. The three subtypes showed widely different patterns in tumor genetic distortion, immune cell composition, cytokine profile, and so on, verifying that the immune-enhanced C2 subtype was associated with better prognosis. In addition, the stroma-deficient C1 subtype may be more efficient for the immune response than the C3 subtype. Furthermore, using WGCNA on the IRGs of those three subtypes, we found two C2-positive gene modules closely related to infection- and immune-associated pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, and the two modules had 22 common pathways.Conclusion: This study improves the power for prognosis prediction and develops new therapeutic strategies to stratify HNSCC patients into clinically significant groups through TIME-related prognostic signature.https://www.frontiersin.org/articles/10.3389/fgene.2022.860712/fullbioinformaticsimmune microenvironmentprognosisclinically significant groupshead and neck squamous cell carcinoma |
| spellingShingle | Kaixin Su Kaixin Su Kaixin Su Kaixin Su Kaixin Su Kaixin Su Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Zekun Zhou Qiao Yi Qiao Yi Qiao Yi Qiao Yi Qiao Yi Qiao Yi Junjie Liu Junjie Liu Junjie Liu Junjie Liu Junjie Liu Junjie Liu Tiao Luo Tiao Luo Tiao Luo Tiao Luo Tiao Luo Tiao Luo Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Xinyan Cui Haixia Zhang Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma Frontiers in Genetics bioinformatics immune microenvironment prognosis clinically significant groups head and neck squamous cell carcinoma |
| title | Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma |
| title_full | Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma |
| title_fullStr | Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma |
| title_short | Systemic Analysis on the Features of Immune Microenvironment Related to Prognostic Signature in Head and Neck Squamous Cell Carcinoma |
| title_sort | systemic analysis on the features of immune microenvironment related to prognostic signature in head and neck squamous cell carcinoma |
| topic | bioinformatics immune microenvironment prognosis clinically significant groups head and neck squamous cell carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.860712/full |
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