Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET)
<p>Abstract</p> <p>Background</p> <p>The Hypertension in the Very Elderly Trial (HYVET) is a placebo controlled double blind trial of treating hypertension with indapamide Slow Release (SR) ± perindopril in subjects over the age of 80 years. The primary endpoints are st...
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| Format: | Article |
| Language: | English |
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BMC
2006-12-01
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| Series: | Trials |
| Online Access: | http://www.trialsjournal.com/content/7/1/33 |
| _version_ | 1818515648418938880 |
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| author | Thijs Lutgarde Staessen Jan A Peters Ruth Bulpitt Christopher J De Vernejoul Marie-Christine Fletcher Astrid E Beckett Nigel S |
| author_facet | Thijs Lutgarde Staessen Jan A Peters Ruth Bulpitt Christopher J De Vernejoul Marie-Christine Fletcher Astrid E Beckett Nigel S |
| author_sort | Thijs Lutgarde |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The Hypertension in the Very Elderly Trial (HYVET) is a placebo controlled double blind trial of treating hypertension with indapamide Slow Release (SR) ± perindopril in subjects over the age of 80 years. The primary endpoints are stroke (fatal and non fatal). In view of the fact that thiazide diuretics and indapamide reduce urinary calcium and may increase bone mineral density, a fracture sub study was designed to investigate whether or not the trial anti-hypertensive treatment will reduce the fracture rate in very elderly hypertensive subjects.</p> <p>Methods</p> <p>In the trial considerable care is taken to ascertain any fractures and to identify risk factors for fracture, such as falls, co-morbidity, drug treatment, smoking and drinking habits, levels of activity, biochemical abnormalities, cardiac irregularities, impaired cognitive function and symptoms of orthostatic hypotension.</p> <p>Potential results</p> <p>The trial is expected to provide 10,500 patient years of follow-up. Given a fracture rate of 40/1000 patient years and a 20% difference in fracture rate, the power of the sub study is 58% to detect this difference at the 5% level of significance. The corresponding power for a reduction of 25% is 78%.</p> <p>Conclusion</p> <p>The trial is well under way, expected to complete in 2009, and on target to detect, if present, the above differences in fracture rate.</p> |
| first_indexed | 2024-12-11T00:31:32Z |
| format | Article |
| id | doaj.art-818b505427e34823a069f8808268a713 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-11T00:31:32Z |
| publishDate | 2006-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-818b505427e34823a069f8808268a7132022-12-22T01:27:20ZengBMCTrials1745-62152006-12-01713310.1186/1745-6215-7-33Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET)Thijs LutgardeStaessen Jan APeters RuthBulpitt Christopher JDe Vernejoul Marie-ChristineFletcher Astrid EBeckett Nigel S<p>Abstract</p> <p>Background</p> <p>The Hypertension in the Very Elderly Trial (HYVET) is a placebo controlled double blind trial of treating hypertension with indapamide Slow Release (SR) ± perindopril in subjects over the age of 80 years. The primary endpoints are stroke (fatal and non fatal). In view of the fact that thiazide diuretics and indapamide reduce urinary calcium and may increase bone mineral density, a fracture sub study was designed to investigate whether or not the trial anti-hypertensive treatment will reduce the fracture rate in very elderly hypertensive subjects.</p> <p>Methods</p> <p>In the trial considerable care is taken to ascertain any fractures and to identify risk factors for fracture, such as falls, co-morbidity, drug treatment, smoking and drinking habits, levels of activity, biochemical abnormalities, cardiac irregularities, impaired cognitive function and symptoms of orthostatic hypotension.</p> <p>Potential results</p> <p>The trial is expected to provide 10,500 patient years of follow-up. Given a fracture rate of 40/1000 patient years and a 20% difference in fracture rate, the power of the sub study is 58% to detect this difference at the 5% level of significance. The corresponding power for a reduction of 25% is 78%.</p> <p>Conclusion</p> <p>The trial is well under way, expected to complete in 2009, and on target to detect, if present, the above differences in fracture rate.</p>http://www.trialsjournal.com/content/7/1/33 |
| spellingShingle | Thijs Lutgarde Staessen Jan A Peters Ruth Bulpitt Christopher J De Vernejoul Marie-Christine Fletcher Astrid E Beckett Nigel S Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET) Trials |
| title | Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET) |
| title_full | Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET) |
| title_fullStr | Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET) |
| title_full_unstemmed | Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET) |
| title_short | Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET) |
| title_sort | fracture risk and the use of a diuretic indapamide sr perindopril a substudy of the hypertension in the very elderly trial hyvet |
| url | http://www.trialsjournal.com/content/7/1/33 |
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