Patterns of Focal Amyloid Deposition Using <sup>18</sup>F-Florbetaben PET in Patients with Cognitive Impairment
Accumulation of aggregated amyloid-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> (A<inline-formula&g...
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MDPI AG
2022-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/6/1357 |
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| author | Sung-eun Chung Hyung-Ji Kim Sungyang Jo Sunju Lee Yoojin Lee Jee Hoon Roh Jae-Hong Lee |
| author_facet | Sung-eun Chung Hyung-Ji Kim Sungyang Jo Sunju Lee Yoojin Lee Jee Hoon Roh Jae-Hong Lee |
| author_sort | Sung-eun Chung |
| collection | DOAJ |
| description | Accumulation of aggregated amyloid-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> (A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula>) in the brain is considered the first pathological event within the pathogenesis of Alzheimer’s disease (AD). It is difficult to accurately identify the initial brain regions of A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> accumulation due to the time-lag between the start of the pathophysiology and symptom onset. However, focal regional amyloid uptake on amyloid PET scans may provide insights into this. Hence, we aimed to evaluate the topographic distribution of amyloid deposition in patients with cognitive impairment and to identify the starting order of amyloid accumulation in the brain using conditional probability. We enrolled 58 patients composed of 9 normal cognition (NC), 32 mild cognitive impairment (MCI), and 17 dementia showing focal regional amyloid deposition corresponding to a brain amyloid plaque load (BAPL) score of 2 among those who visited the Memory Clinic of Asan Medical Center and underwent an <sup>18</sup>F-florbetaben PET scan (March 2013 to April 2019). Regions of interest (ROI) included the frontal, parietal, lateral temporal, and occipital cortices, the posterior cingulate/precuneus, and the striatum. The most frequent occurrence of A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> deposition was in the posterior cingulate/precuneus (n = 41, 68.3%). The second most frequent site was the lateral temporal cortex (n = 24, 40.0%), followed by the lateral parietal cortex (n = 21, 35.6%) and other lesions, such as the frontal and occipital cortices. The striatum was the least frequently affected. Our study found that the posterior cingulate/precuneus and the lateral temporal and parietal cortices may be the earliest areas to be affected by A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> accumulation. Longitudinal follow-up of focal brain amyloid deposition may help elucidate the evolutionary pattern of A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> accumulation in the brain of people with AD continuum. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:00:29Z |
| publishDate | 2022-05-01 |
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| series | Diagnostics |
| spelling | doaj.art-818d5463d6cc4c94ba575ea13021c8f82023-11-23T16:16:49ZengMDPI AGDiagnostics2075-44182022-05-01126135710.3390/diagnostics12061357Patterns of Focal Amyloid Deposition Using <sup>18</sup>F-Florbetaben PET in Patients with Cognitive ImpairmentSung-eun Chung0Hyung-Ji Kim1Sungyang Jo2Sunju Lee3Yoojin Lee4Jee Hoon Roh5Jae-Hong Lee6Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaNeuroscience Institute, Korea University College of Medicine, Seoul 02852, KoreaDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaAccumulation of aggregated amyloid-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> (A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula>) in the brain is considered the first pathological event within the pathogenesis of Alzheimer’s disease (AD). It is difficult to accurately identify the initial brain regions of A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> accumulation due to the time-lag between the start of the pathophysiology and symptom onset. However, focal regional amyloid uptake on amyloid PET scans may provide insights into this. Hence, we aimed to evaluate the topographic distribution of amyloid deposition in patients with cognitive impairment and to identify the starting order of amyloid accumulation in the brain using conditional probability. We enrolled 58 patients composed of 9 normal cognition (NC), 32 mild cognitive impairment (MCI), and 17 dementia showing focal regional amyloid deposition corresponding to a brain amyloid plaque load (BAPL) score of 2 among those who visited the Memory Clinic of Asan Medical Center and underwent an <sup>18</sup>F-florbetaben PET scan (March 2013 to April 2019). Regions of interest (ROI) included the frontal, parietal, lateral temporal, and occipital cortices, the posterior cingulate/precuneus, and the striatum. The most frequent occurrence of A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> deposition was in the posterior cingulate/precuneus (n = 41, 68.3%). The second most frequent site was the lateral temporal cortex (n = 24, 40.0%), followed by the lateral parietal cortex (n = 21, 35.6%) and other lesions, such as the frontal and occipital cortices. The striatum was the least frequently affected. Our study found that the posterior cingulate/precuneus and the lateral temporal and parietal cortices may be the earliest areas to be affected by A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> accumulation. Longitudinal follow-up of focal brain amyloid deposition may help elucidate the evolutionary pattern of A<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="sans-serif">β</mi></semantics></math></inline-formula> accumulation in the brain of people with AD continuum.https://www.mdpi.com/2075-4418/12/6/1357Alzheimer’s diseaseamyloid beta 42conditional probability |
| spellingShingle | Sung-eun Chung Hyung-Ji Kim Sungyang Jo Sunju Lee Yoojin Lee Jee Hoon Roh Jae-Hong Lee Patterns of Focal Amyloid Deposition Using <sup>18</sup>F-Florbetaben PET in Patients with Cognitive Impairment Diagnostics Alzheimer’s disease amyloid beta 42 conditional probability |
| title | Patterns of Focal Amyloid Deposition Using <sup>18</sup>F-Florbetaben PET in Patients with Cognitive Impairment |
| title_full | Patterns of Focal Amyloid Deposition Using <sup>18</sup>F-Florbetaben PET in Patients with Cognitive Impairment |
| title_fullStr | Patterns of Focal Amyloid Deposition Using <sup>18</sup>F-Florbetaben PET in Patients with Cognitive Impairment |
| title_full_unstemmed | Patterns of Focal Amyloid Deposition Using <sup>18</sup>F-Florbetaben PET in Patients with Cognitive Impairment |
| title_short | Patterns of Focal Amyloid Deposition Using <sup>18</sup>F-Florbetaben PET in Patients with Cognitive Impairment |
| title_sort | patterns of focal amyloid deposition using sup 18 sup f florbetaben pet in patients with cognitive impairment |
| topic | Alzheimer’s disease amyloid beta 42 conditional probability |
| url | https://www.mdpi.com/2075-4418/12/6/1357 |
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