The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis evaluated the efficacy of dexlansoprazole (a proton pump inhibitor—PPI) in resolving heartburn, reflux, and other symptoms and complications resulting from gastroesophageal reflux disease (GERD). The study followed PRISMA 2020 and was registered in PROSPERO (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/1247 |
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| author | Gabriel Pereira Nunes Thayná Cerqueira Silveira João Vítor Silveira Marciano Alexandre Henrique dos Reis-Prado Tulio Morandin Ferrisse Evandro Barbosa dos Anjos Maria Helena Fernandes |
| author_facet | Gabriel Pereira Nunes Thayná Cerqueira Silveira João Vítor Silveira Marciano Alexandre Henrique dos Reis-Prado Tulio Morandin Ferrisse Evandro Barbosa dos Anjos Maria Helena Fernandes |
| author_sort | Gabriel Pereira Nunes |
| collection | DOAJ |
| description | This systematic review and meta-analysis evaluated the efficacy of dexlansoprazole (a proton pump inhibitor—PPI) in resolving heartburn, reflux, and other symptoms and complications resulting from gastroesophageal reflux disease (GERD). The study followed PRISMA 2020 and was registered in PROSPERO (CRD42020206513). The search strategy used MeSH and free terms appropriately adapted for each database. Only randomized clinical trials (RCTs) were included. The Cochrane tool (RoB 2.0) was used to assess the risk of bias, and the certainty of evidence was rated using GRADE. Ten RCTs were included. Dexlansoprazole outperformed the placebo and other PPIs in the resolution of heartburn and reflux symptoms in patients with GERD, with benefits during and after treatment, especially in those with moderate and severe symptoms. The meta-analyses indicated that dexlansoprazole at doses of 30 and 60 mg had more 24 h heartburn-free days and nights compared to the placebo medications; no difference was reported between dexlansoprazole at doses of 30 and 60 mg in heartburn-free nights. A low bias risk and a moderate certainty of evidence were observed. This review confirms the therapeutic effect of dexlansoprazole (placebo-controlled) and its improvements in GERD symptoms compared to another PPI. However, the interpretation of the results should be carried out cautiously due to the small number of included studies and other reported limitations. |
| first_indexed | 2024-03-08T09:52:58Z |
| format | Article |
| id | doaj.art-818e6166724f496fb4b71f5d06552d4e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:52:58Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-818e6166724f496fb4b71f5d06552d4e2024-01-29T13:58:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01252124710.3390/ijms25021247The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-AnalysisGabriel Pereira Nunes0Thayná Cerqueira Silveira1João Vítor Silveira Marciano2Alexandre Henrique dos Reis-Prado3Tulio Morandin Ferrisse4Evandro Barbosa dos Anjos5Maria Helena Fernandes6Department of Restorative and Preventive Dentistry, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16018-805, BrazilDepartment of Medicine, Institute of Health Sciences (ICS), United Colleges of Northern Minas (FUNORTE), Montes Claros 39404-006, BrazilDepartment of Medicine, Institute of Health Sciences (ICS), United Colleges of Northern Minas (FUNORTE), Montes Claros 39404-006, BrazilDepartment of Restorative Dentistry, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, BrazilDepartment of Diagnosis, Surgery and Oral Medicine, School of Dentistry, São Paulo State University (UNESP), Araraquara 14801-385, BrazilDepartment of Medicine, Institute of Health Sciences (ICS), United Colleges of Northern Minas (FUNORTE), Montes Claros 39404-006, BrazilLaboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, 4160-007 Porto, PortugalThis systematic review and meta-analysis evaluated the efficacy of dexlansoprazole (a proton pump inhibitor—PPI) in resolving heartburn, reflux, and other symptoms and complications resulting from gastroesophageal reflux disease (GERD). The study followed PRISMA 2020 and was registered in PROSPERO (CRD42020206513). The search strategy used MeSH and free terms appropriately adapted for each database. Only randomized clinical trials (RCTs) were included. The Cochrane tool (RoB 2.0) was used to assess the risk of bias, and the certainty of evidence was rated using GRADE. Ten RCTs were included. Dexlansoprazole outperformed the placebo and other PPIs in the resolution of heartburn and reflux symptoms in patients with GERD, with benefits during and after treatment, especially in those with moderate and severe symptoms. The meta-analyses indicated that dexlansoprazole at doses of 30 and 60 mg had more 24 h heartburn-free days and nights compared to the placebo medications; no difference was reported between dexlansoprazole at doses of 30 and 60 mg in heartburn-free nights. A low bias risk and a moderate certainty of evidence were observed. This review confirms the therapeutic effect of dexlansoprazole (placebo-controlled) and its improvements in GERD symptoms compared to another PPI. However, the interpretation of the results should be carried out cautiously due to the small number of included studies and other reported limitations.https://www.mdpi.com/1422-0067/25/2/1247gastroesophageal refluxPPIdexlansoprazolesystematic reviewmeta-analysis |
| spellingShingle | Gabriel Pereira Nunes Thayná Cerqueira Silveira João Vítor Silveira Marciano Alexandre Henrique dos Reis-Prado Tulio Morandin Ferrisse Evandro Barbosa dos Anjos Maria Helena Fernandes The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis International Journal of Molecular Sciences gastroesophageal reflux PPI dexlansoprazole systematic review meta-analysis |
| title | The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis |
| title_full | The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis |
| title_short | The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis |
| title_sort | effect of dexlansoprazole on gastroesophageal reflux disease a systematic review and meta analysis |
| topic | gastroesophageal reflux PPI dexlansoprazole systematic review meta-analysis |
| url | https://www.mdpi.com/1422-0067/25/2/1247 |
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