Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System
The Dmrt genes encode the transcription factor containing the DM (doublesex and mab-3) domain, an intertwined zinc finger-like DNA binding module. While Dmrt genes are mainly involved in the sexual development of various species, recent studies have revealed that Dmrt genes, which belong to the Dmrt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.789583/full |
| _version_ | 1830085061476614144 |
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| author | Takako Kikkawa Noriko Osumi |
| author_facet | Takako Kikkawa Noriko Osumi |
| author_sort | Takako Kikkawa |
| collection | DOAJ |
| description | The Dmrt genes encode the transcription factor containing the DM (doublesex and mab-3) domain, an intertwined zinc finger-like DNA binding module. While Dmrt genes are mainly involved in the sexual development of various species, recent studies have revealed that Dmrt genes, which belong to the DmrtA subfamily, are differentially expressed in the embryonic brain and spinal cord and are essential for the development of the central nervous system. Herein, we summarize recent studies that reveal the multiple functions of the Dmrt genes in various aspects of vertebrate neural development, including brain patterning, neurogenesis, and the specification of neurons. |
| first_indexed | 2024-12-14T16:53:22Z |
| format | Article |
| id | doaj.art-818ee3a4d8f74cbb933732164135a315 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-14T16:53:22Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-818ee3a4d8f74cbb933732164135a3152022-12-21T22:54:01ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-12-011510.3389/fnins.2021.789583789583Multiple Functions of the Dmrt Genes in the Development of the Central Nervous SystemTakako KikkawaNoriko OsumiThe Dmrt genes encode the transcription factor containing the DM (doublesex and mab-3) domain, an intertwined zinc finger-like DNA binding module. While Dmrt genes are mainly involved in the sexual development of various species, recent studies have revealed that Dmrt genes, which belong to the DmrtA subfamily, are differentially expressed in the embryonic brain and spinal cord and are essential for the development of the central nervous system. Herein, we summarize recent studies that reveal the multiple functions of the Dmrt genes in various aspects of vertebrate neural development, including brain patterning, neurogenesis, and the specification of neurons.https://www.frontiersin.org/articles/10.3389/fnins.2021.789583/fullDmrtA subfamilypatterningneurogenesisneuronal specificationcorticogenesis |
| spellingShingle | Takako Kikkawa Noriko Osumi Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System Frontiers in Neuroscience DmrtA subfamily patterning neurogenesis neuronal specification corticogenesis |
| title | Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System |
| title_full | Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System |
| title_fullStr | Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System |
| title_full_unstemmed | Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System |
| title_short | Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System |
| title_sort | multiple functions of the dmrt genes in the development of the central nervous system |
| topic | DmrtA subfamily patterning neurogenesis neuronal specification corticogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.789583/full |
| work_keys_str_mv | AT takakokikkawa multiplefunctionsofthedmrtgenesinthedevelopmentofthecentralnervoussystem AT norikoosumi multiplefunctionsofthedmrtgenesinthedevelopmentofthecentralnervoussystem |