Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysis
Objective: The effect of oxygen therapy on the prognosis of chronic obstructive pulmonary disease (COPD) with nocturnal hypoxemia (NOD) has been controversial. Therefore, this study systematically evaluated the relevant literature and included it into randomized controlled studies for meta-analysis...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1123945/full |
| _version_ | 1828717581607895040 |
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| author | Ling Sun Ya-Fei Chang Yun-Fei Wang Xian-Zhong Ran Xiang-Rong Li Quan-Xin Xie Bin Ning |
| author_facet | Ling Sun Ya-Fei Chang Yun-Fei Wang Xian-Zhong Ran Xiang-Rong Li Quan-Xin Xie Bin Ning |
| author_sort | Ling Sun |
| collection | DOAJ |
| description | Objective: The effect of oxygen therapy on the prognosis of chronic obstructive pulmonary disease (COPD) with nocturnal hypoxemia (NOD) has been controversial. Therefore, this study systematically evaluated the relevant literature and included it into randomized controlled studies for meta-analysis to evaluate the efficacy and prognosis.Methods: We searched PubMed, EMBASE, web of science, Cochrane, China HowNet and Wanfang database for the literature on the prognosis of COPD patients with simple NOD from the establishment of the database to 30 June 2022. The outcome indicators were death and aggravation of the disease. The efficacy evaluation measures were pulmonary function and arterial blood gas results. The publication bias and heterogeneity of the included studies were evaluated.Results: A total of 621 patients from 5 studies were included in this meta-analysis, and there was no publication bias in the included studies. The total mortality of long-term oxygen therapy (LTOT) in COPD patients with simple NOD in oxygen therapy group (RR = 1.04; 95% CI: 0.81–1.33, p = 0.77), mortality (RR = 0.87; 95% CI: 0.58–1.31, p = 0.50), risk of progression to LTOT events (RR = 1.07; 95% CI: 0.76–1.51, p = 0.71). PaO2 in patients with COPD and simple NOD in oxygen therapy group was higher than that in non-oxygen therapy group (mean difference (MD) = 13.47; 95% CI: 3.49–23.46, p = 0.008), the decrease of PaCO2 level was not statistically significant (MD = −10.05; 95% CI: −26.36-6.27, p = 0.23).Conclusion: Oxygen therapy can improve the prognosis of blood oxygen partial pressure in COPD patients with simple NOD, but oxygen therapy has no significant effect on the survival rate, controlling the progression of the disease to LTOT and reducing the partial pressure of carbon dioxide. |
| first_indexed | 2024-03-12T14:30:22Z |
| format | Article |
| id | doaj.art-819033120b0c4428984e9cde541f11ed |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T14:30:22Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-819033120b0c4428984e9cde541f11ed2023-08-17T14:31:43ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-08-011410.3389/fphar.2023.11239451123945Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysisLing Sun0Ya-Fei Chang1Yun-Fei Wang2Xian-Zhong Ran3Xiang-Rong Li4Quan-Xin Xie5Bin Ning6Department of Respiratory and Critical Care Medicine, Fuyang Tumor Hospital, Fuyang, ChinaFaculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Cardiology, The 901th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army, Hefei, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Tumor Hospital, Fuyang, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Tumor Hospital, Fuyang, ChinaDepartment of Respiratory and Critical Care Medicine, Fuyang Tumor Hospital, Fuyang, ChinaDepartment of Cardiology, Fuyang People's Hospital Affiliated to Anhui Medical University, Fuyang, ChinaObjective: The effect of oxygen therapy on the prognosis of chronic obstructive pulmonary disease (COPD) with nocturnal hypoxemia (NOD) has been controversial. Therefore, this study systematically evaluated the relevant literature and included it into randomized controlled studies for meta-analysis to evaluate the efficacy and prognosis.Methods: We searched PubMed, EMBASE, web of science, Cochrane, China HowNet and Wanfang database for the literature on the prognosis of COPD patients with simple NOD from the establishment of the database to 30 June 2022. The outcome indicators were death and aggravation of the disease. The efficacy evaluation measures were pulmonary function and arterial blood gas results. The publication bias and heterogeneity of the included studies were evaluated.Results: A total of 621 patients from 5 studies were included in this meta-analysis, and there was no publication bias in the included studies. The total mortality of long-term oxygen therapy (LTOT) in COPD patients with simple NOD in oxygen therapy group (RR = 1.04; 95% CI: 0.81–1.33, p = 0.77), mortality (RR = 0.87; 95% CI: 0.58–1.31, p = 0.50), risk of progression to LTOT events (RR = 1.07; 95% CI: 0.76–1.51, p = 0.71). PaO2 in patients with COPD and simple NOD in oxygen therapy group was higher than that in non-oxygen therapy group (mean difference (MD) = 13.47; 95% CI: 3.49–23.46, p = 0.008), the decrease of PaCO2 level was not statistically significant (MD = −10.05; 95% CI: −26.36-6.27, p = 0.23).Conclusion: Oxygen therapy can improve the prognosis of blood oxygen partial pressure in COPD patients with simple NOD, but oxygen therapy has no significant effect on the survival rate, controlling the progression of the disease to LTOT and reducing the partial pressure of carbon dioxide.https://www.frontiersin.org/articles/10.3389/fphar.2023.1123945/fulloxygen therapyCOPDNODprognosismeta analysis |
| spellingShingle | Ling Sun Ya-Fei Chang Yun-Fei Wang Xian-Zhong Ran Xiang-Rong Li Quan-Xin Xie Bin Ning Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysis Frontiers in Pharmacology oxygen therapy COPD NOD prognosis meta analysis |
| title | Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysis |
| title_full | Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysis |
| title_fullStr | Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysis |
| title_full_unstemmed | Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysis |
| title_short | Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysis |
| title_sort | prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in copd a meta analysis |
| topic | oxygen therapy COPD NOD prognosis meta analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1123945/full |
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