Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

This review describes the formation of six-membered heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions. The review is divided according to the main he...

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Main Authors: Mohsine Driowya, Aziza Saber, Hamid Marzag, Luc Demange, Rachid Benhida, Khalid Bougrin
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/21/4/492
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author Mohsine Driowya
Aziza Saber
Hamid Marzag
Luc Demange
Rachid Benhida
Khalid Bougrin
author_facet Mohsine Driowya
Aziza Saber
Hamid Marzag
Luc Demange
Rachid Benhida
Khalid Bougrin
author_sort Mohsine Driowya
collection DOAJ
description This review describes the formation of six-membered heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions. The review is divided according to the main heterocycle types in order of increasing complexity, starting with heterocyclic systems containing one, two and three heteroatoms and their fused analogues. Recent microwave applications are reviewed, with special focus on the chemistry of bioactive compounds. Selected examples from the 2006 to 2015 literature are discussed.
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spelling doaj.art-8190761d52194709941a69195ddc93a42022-12-21T19:20:49ZengMDPI AGMolecules1420-30492016-04-0121449210.3390/molecules21040492molecules21040492Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused AnaloguesMohsine Driowya0Aziza Saber1Hamid Marzag2Luc Demange3Rachid Benhida4Khalid Bougrin5Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, MarocLaboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, MarocLaboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, MarocInstitut de Chimie de Nice, ICN UMR UNS CNRS 7272, Université Nice-Sophia Antipolis-Université Côte d’Azur, Parc Valrose, 06108 Nice Cedex 2, FranceInstitut de Chimie de Nice, ICN UMR UNS CNRS 7272, Université Nice-Sophia Antipolis-Université Côte d’Azur, Parc Valrose, 06108 Nice Cedex 2, FranceLaboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, MarocThis review describes the formation of six-membered heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions. The review is divided according to the main heterocycle types in order of increasing complexity, starting with heterocyclic systems containing one, two and three heteroatoms and their fused analogues. Recent microwave applications are reviewed, with special focus on the chemistry of bioactive compounds. Selected examples from the 2006 to 2015 literature are discussed.http://www.mdpi.com/1420-3049/21/4/492microwave irradiationbioactive moleculescycloadditioncyclocondensationmulticomponent reactions
spellingShingle Mohsine Driowya
Aziza Saber
Hamid Marzag
Luc Demange
Rachid Benhida
Khalid Bougrin
Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues
Molecules
microwave irradiation
bioactive molecules
cycloaddition
cyclocondensation
multicomponent reactions
title Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues
title_full Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues
title_fullStr Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues
title_full_unstemmed Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues
title_short Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues
title_sort microwave assisted synthesis of bioactive six membered heterocycles and their fused analogues
topic microwave irradiation
bioactive molecules
cycloaddition
cyclocondensation
multicomponent reactions
url http://www.mdpi.com/1420-3049/21/4/492
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AT hamidmarzag microwaveassistedsynthesisofbioactivesixmemberedheterocyclesandtheirfusedanalogues
AT lucdemange microwaveassistedsynthesisofbioactivesixmemberedheterocyclesandtheirfusedanalogues
AT rachidbenhida microwaveassistedsynthesisofbioactivesixmemberedheterocyclesandtheirfusedanalogues
AT khalidbougrin microwaveassistedsynthesisofbioactivesixmemberedheterocyclesandtheirfusedanalogues