Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacy
ABSTRACTMicrobiome-targeting therapies have received great attention as approaches to prevent disease in infants born preterm, but their safety and efficacy remain uncertain. Here we summarize the existing literature, focusing on recent meta-analyses and systematic reviews that evaluate the performa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2221758 |
| _version_ | 1797236661100216320 |
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| author | Anna DeVeaux Jian Ryou Gautam Dantas Barbara B. Warner Phillip I. Tarr |
| author_facet | Anna DeVeaux Jian Ryou Gautam Dantas Barbara B. Warner Phillip I. Tarr |
| author_sort | Anna DeVeaux |
| collection | DOAJ |
| description | ABSTRACTMicrobiome-targeting therapies have received great attention as approaches to prevent disease in infants born preterm, but their safety and efficacy remain uncertain. Here we summarize the existing literature, focusing on recent meta-analyses and systematic reviews that evaluate the performance of probiotics, prebiotics, and/or synbiotics in clinical trials and studies, emphasizing interventions for which the primary or secondary outcomes were prevention of necrotizing enterocolitis, late-onset sepsis, feeding intolerance, and/or reduction in hospitalization length or all-cause mortality. Current evidence suggests that probiotics and prebiotics are largely safe but conclusions regarding their effectiveness in the neonatal intensive care unit have been mixed. To address this ambiguity, we evaluated publications that collectively support benefits of probiotics with moderate to high certainty evidence in a recent comprehensive network meta-analysis, highlighting limitations in these trials that make it difficult to support with confidence the routine, universal administration of probiotics to preterm infants. |
| first_indexed | 2024-03-11T14:20:28Z |
| format | Article |
| id | doaj.art-819088b96f1646a68f8e525aceb103ff |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:24Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-819088b96f1646a68f8e525aceb103ff2024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2221758Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacyAnna DeVeaux0Jian Ryou1Gautam Dantas2Barbara B. Warner3Phillip I. Tarr4The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USAThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USAThe Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USADepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USADepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USAABSTRACTMicrobiome-targeting therapies have received great attention as approaches to prevent disease in infants born preterm, but their safety and efficacy remain uncertain. Here we summarize the existing literature, focusing on recent meta-analyses and systematic reviews that evaluate the performance of probiotics, prebiotics, and/or synbiotics in clinical trials and studies, emphasizing interventions for which the primary or secondary outcomes were prevention of necrotizing enterocolitis, late-onset sepsis, feeding intolerance, and/or reduction in hospitalization length or all-cause mortality. Current evidence suggests that probiotics and prebiotics are largely safe but conclusions regarding their effectiveness in the neonatal intensive care unit have been mixed. To address this ambiguity, we evaluated publications that collectively support benefits of probiotics with moderate to high certainty evidence in a recent comprehensive network meta-analysis, highlighting limitations in these trials that make it difficult to support with confidence the routine, universal administration of probiotics to preterm infants.https://www.tandfonline.com/doi/10.1080/19490976.2023.2221758Preterm infantsprobioticsprebioticssynbioticsnecrotizing enterocolitislate-onset sepsis |
| spellingShingle | Anna DeVeaux Jian Ryou Gautam Dantas Barbara B. Warner Phillip I. Tarr Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacy Gut Microbes Preterm infants probiotics prebiotics synbiotics necrotizing enterocolitis late-onset sepsis |
| title | Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacy |
| title_full | Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacy |
| title_fullStr | Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacy |
| title_full_unstemmed | Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacy |
| title_short | Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacy |
| title_sort | microbiome targeting therapies in the neonatal intensive care unit safety and efficacy |
| topic | Preterm infants probiotics prebiotics synbiotics necrotizing enterocolitis late-onset sepsis |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2221758 |
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