High-fat diet impairs glucose homeostasis by increased p16 beta-cell expression and alters glucose homeostasis of the progeny in a parental-sex dependent manner

High-fat diet impairs glucose homeostasis by increased p16 beta-cell expression and alters glucose homeostasis of the progeny in a parental-sex dependent manner

IntroductionObesity consists in the accumulation of adipose tissue accompanied by low grade chronic inflammation and is considered a pandemic disease. Recent studies have observed that obesity affects females and males in a sex-dependent manner. In addition, several works have demonstrated that pare...

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Bibliographic Details
Main Authors: Rene Escalona, Carlos Larqué, Daniela Cortes, Ricardo Vilchis, Emiliano Granados-Delgado, Abigail Sánchez, Guadalupe Sánchez-Bringas, Haydée Lugo-Martínez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Endocrinology
Subjects:
intergenerational
obesity
adiposity
hyperinsulinemia
impaired-glucose tolerance
sexual dimorphism
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1246194/full

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