Arbutin Protects Retinal Pigment Epithelium Against Oxidative Stress by Modulating SIRT1/FOXO3a/PGC-1α/β Pathway

Arbutin Protects Retinal Pigment Epithelium Against Oxidative Stress by Modulating SIRT1/FOXO3a/PGC-1α/β Pathway

Age-related macular degeneration (AMD), which is the leading cause of blindness among the elderly in western societies, is majorly accompanied by retinal pigment epithelium (RPE) degeneration. Because of the irreversible RPE cell loss among oxidative stress, it is crucial to search for available dru...

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Bibliographic Details
Main Authors: Han Tang, Han Du, Xielan Kuang, Hao Huang, Jingshu Zeng, Chongde Long, Binbin Zhu, Licheng Fu, Hua Wang, Qingjiong Zhang, Shuibin Lin, Jianhua Yan, Huangxuan Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Genetics
Subjects:
age-related macular degeneration
oxidative stress
SIRT1 signaling pathway
mitochondrial health
cell senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.922807/full

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