PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) comprise a group of malignant tumors arising from the squamous epithelium of the oral cavity, pharynx, and larynx. HNSCC is the 6th most common cancer in the world, with approximately 650,000 new cases and 400,000 deaths annually. Although survival rates...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023006862 |
| _version_ | 1811161740576030720 |
|---|---|
| author | Siming Gong Changwu Wu Yingjuan Duan Jinfei Fu Yuling Wang Hao Wu Bixi Zhang Juyu Tang Panfeng Wu |
| author_facet | Siming Gong Changwu Wu Yingjuan Duan Jinfei Fu Yuling Wang Hao Wu Bixi Zhang Juyu Tang Panfeng Wu |
| author_sort | Siming Gong |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) comprise a group of malignant tumors arising from the squamous epithelium of the oral cavity, pharynx, and larynx. HNSCC is the 6th most common cancer in the world, with approximately 650,000 new cases and 400,000 deaths annually. Although survival rates have improved, HNSCC therapy may result in short – or long-term morbidity in approximately 50% of cases. Previous studies have also indicated that the overexpression of procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenases (PLOD) family proteins could lead to certain diseases or even tumors. However, there has been no dedicated evaluation of the relationship between PLOD family members and HNSCC. Here we used data from the Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Human Protein Atlas (HPA) databases to explore the potential role of PLOD family proteins in HNSCC. Our evaluations suggest that increased expression of PLOD family proteins may be associated with poorer prognosis and increased immune infiltration in HNSCC, making these proteins a potential biomarker for personalized treatment of HNSCC. |
| first_indexed | 2024-04-10T06:19:37Z |
| format | Article |
| id | doaj.art-81965fff7d954c8e946a9a8e04aaa213 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:19:37Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-81965fff7d954c8e946a9a8e04aaa2132023-03-02T05:01:45ZengElsevierHeliyon2405-84402023-02-0192e13479PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinomaSiming Gong0Changwu Wu1Yingjuan Duan2Jinfei Fu3Yuling Wang4Hao Wu5Bixi Zhang6Juyu Tang7Panfeng Wu8Department of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, China; Institute of Anatomy, University of Leipzig, Leipzig, GermanyInstitute of Anatomy, University of Leipzig, Leipzig, GermanyFaculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, GermanyDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pathology, Hunan Provincial People's Hospital, Hunan Normal University, Changsha, ChinaDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Hand and Microsurgery, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, China; Corresponding author.Head and neck squamous cell carcinoma (HNSCC) comprise a group of malignant tumors arising from the squamous epithelium of the oral cavity, pharynx, and larynx. HNSCC is the 6th most common cancer in the world, with approximately 650,000 new cases and 400,000 deaths annually. Although survival rates have improved, HNSCC therapy may result in short – or long-term morbidity in approximately 50% of cases. Previous studies have also indicated that the overexpression of procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenases (PLOD) family proteins could lead to certain diseases or even tumors. However, there has been no dedicated evaluation of the relationship between PLOD family members and HNSCC. Here we used data from the Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Human Protein Atlas (HPA) databases to explore the potential role of PLOD family proteins in HNSCC. Our evaluations suggest that increased expression of PLOD family proteins may be associated with poorer prognosis and increased immune infiltration in HNSCC, making these proteins a potential biomarker for personalized treatment of HNSCC.http://www.sciencedirect.com/science/article/pii/S2405844023006862Head and neck squamous cell carcinomaPLODsPrognosticTumor microenvironmentImmune infiltrationImmunotherapy |
| spellingShingle | Siming Gong Changwu Wu Yingjuan Duan Jinfei Fu Yuling Wang Hao Wu Bixi Zhang Juyu Tang Panfeng Wu PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma Heliyon Head and neck squamous cell carcinoma PLODs Prognostic Tumor microenvironment Immune infiltration Immunotherapy |
| title | PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma |
| title_full | PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma |
| title_fullStr | PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma |
| title_full_unstemmed | PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma |
| title_short | PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma |
| title_sort | plods novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma |
| topic | Head and neck squamous cell carcinoma PLODs Prognostic Tumor microenvironment Immune infiltration Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023006862 |
| work_keys_str_mv | AT siminggong plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma AT changwuwu plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma AT yingjuanduan plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma AT jinfeifu plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma AT yulingwang plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma AT haowu plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma AT bixizhang plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma AT juyutang plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma AT panfengwu plodsnovelprognosticbiomarkersandpotentialimmunotherapytargetsforheadandnecksquamouscellcarcinoma |