THE INCIDENCE OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS AFFECTED WITH SUBCLINICAL HYPOTHYROIDISM
Background: Numerous studies have identified the presence of adverse cardiovascular effects associated with hypothyroidism. The timely detection of individuals presenting with sub-clinical hypothyroidism has the potential to facilitate prompt intervention, consequently yielding a beneficial impac...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Student's Journal of Health Research
2023-09-01
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| Series: | Student's Journal of Health Research Africa |
| Subjects: | |
| Online Access: | https://sjhresearchafrica.org/index.php/public-html/article/view/676 |
| _version_ | 1797661993313763328 |
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| author | Nirav Kumar Chandra Bhanu Chandan Ravi Vishnu Prasad Gautam Kumar |
| author_facet | Nirav Kumar Chandra Bhanu Chandan Ravi Vishnu Prasad Gautam Kumar |
| author_sort | Nirav Kumar |
| collection | DOAJ |
| description |
Background:
Numerous studies have identified the presence of adverse cardiovascular effects associated with hypothyroidism. The timely detection of individuals presenting with sub-clinical hypothyroidism has the potential to facilitate prompt intervention, consequently yielding a beneficial impact on cardiovascular morbidity and mortality rates.
Objectives:
The primary aim of this study is to investigate the potential correlation between subclinical hypothyroidism and left ventricular dysfunction. Additionally, we aim to explore the relationship between systolic and diastolic dysfunction in patients with subclinical hypothyroidism.
Materials and Methods:
In this study, a total of 60 cases of subclinical hypothyroidism, as well as 30 age- and sex-matched healthy control subjects, were included. Serum levels of thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) were assessed, and individuals exhibiting subclinical hypothyroidism were subsequently subjected to a two-dimensional echocardiogram (2DEcho).
Results:
A statistically significant decrease was observed in peak early filling velocity (PE) (p<0.001) and early filling time velocity integral (Ei) (p<0.001). The statistical analysis revealed a significant reduction in the ratio of early and late peak velocities (PE/PA) (p<0.001), the ratio of time velocity integral of early and atrial filling (Ei/Ai) (p<0.001), and the ratio of the early peak to average velocity (PE/M) (p<0.001). The mean ejection fraction (EF) for the hypothyroid patients was 54.8 ± 5.54, which was slightly lower compared to the control subjects who had a mean EF of 55.6 ± 3.45.
Conclusion:
In conclusion, the findings of this study indicate that sub-clinical hypothyroidism is associated with notable diastolic dysfunction, while systolic function remains largely unaffected.
Recommendation:
TSH and T4 need to be repeated at least once after 2-3 months. TPO antibodies which indicate an autoimmune etiology of hypothyroidism should be measured.
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| first_indexed | 2024-03-11T18:53:42Z |
| format | Article |
| id | doaj.art-8197a732e5974f4c9d29bd9830306309 |
| institution | Directory Open Access Journal |
| issn | 2709-9997 |
| language | English |
| last_indexed | 2024-03-11T18:53:42Z |
| publishDate | 2023-09-01 |
| publisher | Student's Journal of Health Research |
| record_format | Article |
| series | Student's Journal of Health Research Africa |
| spelling | doaj.art-8197a732e5974f4c9d29bd98303063092023-10-11T07:29:02ZengStudent's Journal of Health ResearchStudent's Journal of Health Research Africa2709-99972023-09-014910.51168/sjhrafrica.v4i9.676THE INCIDENCE OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS AFFECTED WITH SUBCLINICAL HYPOTHYROIDISMNirav Kumar0Chandra Bhanu Chandan1Ravi Vishnu Prasad2Gautam Kumar3Department of Cardiology, IGIMS, Patna, Bihar, IndiaDepartment of Cardiology, IGIMS, Patna, Bihar, IndiaDepartment of Cardiology, IGIMS, Patna, Bihar, IndiaDepartment of Cardiology, IGIMS, Patna, Bihar, India Background: Numerous studies have identified the presence of adverse cardiovascular effects associated with hypothyroidism. The timely detection of individuals presenting with sub-clinical hypothyroidism has the potential to facilitate prompt intervention, consequently yielding a beneficial impact on cardiovascular morbidity and mortality rates. Objectives: The primary aim of this study is to investigate the potential correlation between subclinical hypothyroidism and left ventricular dysfunction. Additionally, we aim to explore the relationship between systolic and diastolic dysfunction in patients with subclinical hypothyroidism. Materials and Methods: In this study, a total of 60 cases of subclinical hypothyroidism, as well as 30 age- and sex-matched healthy control subjects, were included. Serum levels of thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) were assessed, and individuals exhibiting subclinical hypothyroidism were subsequently subjected to a two-dimensional echocardiogram (2DEcho). Results: A statistically significant decrease was observed in peak early filling velocity (PE) (p<0.001) and early filling time velocity integral (Ei) (p<0.001). The statistical analysis revealed a significant reduction in the ratio of early and late peak velocities (PE/PA) (p<0.001), the ratio of time velocity integral of early and atrial filling (Ei/Ai) (p<0.001), and the ratio of the early peak to average velocity (PE/M) (p<0.001). The mean ejection fraction (EF) for the hypothyroid patients was 54.8 ± 5.54, which was slightly lower compared to the control subjects who had a mean EF of 55.6 ± 3.45. Conclusion: In conclusion, the findings of this study indicate that sub-clinical hypothyroidism is associated with notable diastolic dysfunction, while systolic function remains largely unaffected. Recommendation: TSH and T4 need to be repeated at least once after 2-3 months. TPO antibodies which indicate an autoimmune etiology of hypothyroidism should be measured. https://sjhresearchafrica.org/index.php/public-html/article/view/676Left ventricular diastolic dysfunctionSubclinical hypothyroidismCardiac dysfunction,DiastolicEchocardiographic evaluation |
| spellingShingle | Nirav Kumar Chandra Bhanu Chandan Ravi Vishnu Prasad Gautam Kumar THE INCIDENCE OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS AFFECTED WITH SUBCLINICAL HYPOTHYROIDISM Student's Journal of Health Research Africa Left ventricular diastolic dysfunction Subclinical hypothyroidism Cardiac dysfunction, Diastolic Echocardiographic evaluation |
| title | THE INCIDENCE OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS AFFECTED WITH SUBCLINICAL HYPOTHYROIDISM |
| title_full | THE INCIDENCE OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS AFFECTED WITH SUBCLINICAL HYPOTHYROIDISM |
| title_fullStr | THE INCIDENCE OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS AFFECTED WITH SUBCLINICAL HYPOTHYROIDISM |
| title_full_unstemmed | THE INCIDENCE OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS AFFECTED WITH SUBCLINICAL HYPOTHYROIDISM |
| title_short | THE INCIDENCE OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS AFFECTED WITH SUBCLINICAL HYPOTHYROIDISM |
| title_sort | incidence of left ventricular diastolic dysfunction in patients affected with subclinical hypothyroidism |
| topic | Left ventricular diastolic dysfunction Subclinical hypothyroidism Cardiac dysfunction, Diastolic Echocardiographic evaluation |
| url | https://sjhresearchafrica.org/index.php/public-html/article/view/676 |
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