Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites
Volumetric absorptive microsampling (VAMS) has arisen as a relevant tool in biological analysis, offering simplified sampling procedures and enhanced stability. Most of the attention VAMS has received in the past decade has been from pharmaceutical research, with most of the published work employing...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/10/1038 |
| _version_ | 1797573029013749760 |
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| author | Daniel Marques de Sá e Silva Marlene Thaitumu Georgios Theodoridis Michael Witting Helen Gika |
| author_facet | Daniel Marques de Sá e Silva Marlene Thaitumu Georgios Theodoridis Michael Witting Helen Gika |
| author_sort | Daniel Marques de Sá e Silva |
| collection | DOAJ |
| description | Volumetric absorptive microsampling (VAMS) has arisen as a relevant tool in biological analysis, offering simplified sampling procedures and enhanced stability. Most of the attention VAMS has received in the past decade has been from pharmaceutical research, with most of the published work employing VAMS targeting drugs or other exogenous compounds, such as toxins and pollutants. However, biomarker analysis by employing blood microsampling has high promise. Herein, a comprehensive review on the applicability of VAMS devices for the analysis of endogenous metabolites/biomarkers was performed. The study presents a full overview of the analysis process, incorporating all the steps in sample treatment and validation parameters. Overall, VAMS devices have proven to be reliable tools for the analysis of endogenous analytes with biological importance, often offering improved analyte stability in comparison with blood under ambient conditions as well as a convenient and straightforward sample acquisition model. |
| first_indexed | 2024-03-10T21:03:37Z |
| format | Article |
| id | doaj.art-8199cb2c7d53422d97dfc9c2a0b62361 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T21:03:37Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-8199cb2c7d53422d97dfc9c2a0b623612023-11-19T17:19:34ZengMDPI AGMetabolites2218-19892023-09-011310103810.3390/metabo13101038Volumetric Absorptive Microsampling in the Analysis of Endogenous MetabolitesDaniel Marques de Sá e Silva0Marlene Thaitumu1Georgios Theodoridis2Michael Witting3Helen Gika4Department of Chemistry, Aristotle University of Thessaloniki (AUTH), 54124 Thessaloniki, GreeceBiomic_AUTh, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, B1.4, 57001 Thessaloniki, GreeceDepartment of Chemistry, Aristotle University of Thessaloniki (AUTH), 54124 Thessaloniki, GreeceMetabolomics and Proteomics Core, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyBiomic_AUTh, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, B1.4, 57001 Thessaloniki, GreeceVolumetric absorptive microsampling (VAMS) has arisen as a relevant tool in biological analysis, offering simplified sampling procedures and enhanced stability. Most of the attention VAMS has received in the past decade has been from pharmaceutical research, with most of the published work employing VAMS targeting drugs or other exogenous compounds, such as toxins and pollutants. However, biomarker analysis by employing blood microsampling has high promise. Herein, a comprehensive review on the applicability of VAMS devices for the analysis of endogenous metabolites/biomarkers was performed. The study presents a full overview of the analysis process, incorporating all the steps in sample treatment and validation parameters. Overall, VAMS devices have proven to be reliable tools for the analysis of endogenous analytes with biological importance, often offering improved analyte stability in comparison with blood under ambient conditions as well as a convenient and straightforward sample acquisition model.https://www.mdpi.com/2218-1989/13/10/1038volumetric absorptive microsampling (VAMS)blood microsamplingendogenous metabolitesbiomarkersanalytical validationclinical application |
| spellingShingle | Daniel Marques de Sá e Silva Marlene Thaitumu Georgios Theodoridis Michael Witting Helen Gika Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites Metabolites volumetric absorptive microsampling (VAMS) blood microsampling endogenous metabolites biomarkers analytical validation clinical application |
| title | Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites |
| title_full | Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites |
| title_fullStr | Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites |
| title_full_unstemmed | Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites |
| title_short | Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites |
| title_sort | volumetric absorptive microsampling in the analysis of endogenous metabolites |
| topic | volumetric absorptive microsampling (VAMS) blood microsampling endogenous metabolites biomarkers analytical validation clinical application |
| url | https://www.mdpi.com/2218-1989/13/10/1038 |
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