Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
A flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) w...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2011-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700019&lng=en&tlng=en |
| _version_ | 1818962440391491584 |
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| author | Erlando Schmidt Jr Wanessa R Melchert Fábio R. P Rocha |
| author_facet | Erlando Schmidt Jr Wanessa R Melchert Fábio R. P Rocha |
| author_sort | Erlando Schmidt Jr |
| collection | DOAJ |
| description | A flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2'-biquinoline 4,4'-dicarboxylic acid. Linear responses were achieved in the µmol L-1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 µg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level. |
| first_indexed | 2024-12-20T12:29:21Z |
| format | Article |
| id | doaj.art-819b371ed22a47559309e83c9ce171e9 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-20T12:29:21Z |
| publishDate | 2011-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-819b371ed22a47559309e83c9ce171e92022-12-21T19:40:46ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642011-01-013471205121010.1590/S0100-40422011000700019S0100-40422011000700019Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacosErlando Schmidt Jr0Wanessa R Melchert1Fábio R. P Rocha2Universidade de São PauloUniversidade de São PauloUniversidade de São PauloA flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2'-biquinoline 4,4'-dicarboxylic acid. Linear responses were achieved in the µmol L-1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 µg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700019&lng=en&tlng=enflow analysispharmaceuticalssequential determination |
| spellingShingle | Erlando Schmidt Jr Wanessa R Melchert Fábio R. P Rocha Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos Química Nova flow analysis pharmaceuticals sequential determination |
| title | Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos |
| title_full | Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos |
| title_fullStr | Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos |
| title_full_unstemmed | Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos |
| title_short | Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos |
| title_sort | sistema de analises em fluxo polivalente para a determinacao espectrofotometrica de farmacos |
| topic | flow analysis pharmaceuticals sequential determination |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700019&lng=en&tlng=en |
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