Role of Tribulus terrestris Against Cadmium-induced Toxicity on Thyroid Gland of Adult Male Albino Rats
Tribulus terrestris (Tt) is a herb distributed worldwide due to its beneficial claims on many diseases. This study aimed to study the role of Tt against Cadmium (Cd)-induced toxicity on thyroid gland of adult male albino rats. Twenty-four rats were subdivided into four groups; (Control group) witho...
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| Format: | Article |
| Language: | English |
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Assiut University
2023-04-01
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| Series: | Journal of Advanced Veterinary Research |
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| Online Access: | https://advetresearch.com/index.php/AVR/article/view/1172 |
| _version_ | 1797657057167409152 |
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| author | Eman Ahmed Negm Alshaimaa A. Alghriany |
| author_facet | Eman Ahmed Negm Alshaimaa A. Alghriany |
| author_sort | Eman Ahmed Negm |
| collection | DOAJ |
| description |
Tribulus terrestris (Tt) is a herb distributed worldwide due to its beneficial claims on many diseases. This study aimed to study the role of Tt against Cadmium (Cd)-induced toxicity on thyroid gland of adult male albino rats. Twenty-four rats were subdivided into four groups; (Control group) without any treatment, (Tt + Cd group) with a daily oral dose of Tt (5 mg/ kg b. wt.) for eight weeks, from the beginning of the ninth week, they injected i.p. with 2 mg/kg of CdCl4 for 8 days, (Cd group) injected i.p. with 2 mg/kg of CdCl4 for 8 days, (Cd + Tt group) injected i.p. with 2 mg/kg of CdCl4 for eight days, from the ninth day they were given a daily oral dose of Tt (5 mg/ kg b. wt.) for eight weeks. Results revealed that levels of T4 and TAC decreased while levels of TSH and MDA increased in Cd group resulted in follicular cells degeneration, increasing the amount of collagen fibers, and increased positive immunoreactivity of PCNA. Administration of Tt before Cd injection increased levels of T4 and TAC while decreased levels of TSH and MDA. administration of Tt after Cd injection didn't affect T4, TSH, MDA and TAC levels. The pre-treatment with Tt protects the thyroid tissue from those destructive changes by Cd while the post-treatment did not treat them. In conclusion, Tribulus terrestris is highly effective in shielding the thyroid gland from further damaging effects of Cd -induced oxidative stress when utilized as prophylactic antioxidant rather than treatment therapy.
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| first_indexed | 2024-03-11T17:38:52Z |
| format | Article |
| id | doaj.art-819e227b5235421286859d25280dd9c4 |
| institution | Directory Open Access Journal |
| issn | 2090-6269 2090-6277 |
| language | English |
| last_indexed | 2024-03-11T17:38:52Z |
| publishDate | 2023-04-01 |
| publisher | Assiut University |
| record_format | Article |
| series | Journal of Advanced Veterinary Research |
| spelling | doaj.art-819e227b5235421286859d25280dd9c42023-10-18T14:22:13ZengAssiut UniversityJournal of Advanced Veterinary Research2090-62692090-62772023-04-01132Role of Tribulus terrestris Against Cadmium-induced Toxicity on Thyroid Gland of Adult Male Albino RatsEman Ahmed Negm0Alshaimaa A. Alghriany1Department of Physiology, Faculty of Veterinary Medicine, Assiut University, Egypt.Departement of Zoology, Faculty of Science, Assiut University, Egypt. Tribulus terrestris (Tt) is a herb distributed worldwide due to its beneficial claims on many diseases. This study aimed to study the role of Tt against Cadmium (Cd)-induced toxicity on thyroid gland of adult male albino rats. Twenty-four rats were subdivided into four groups; (Control group) without any treatment, (Tt + Cd group) with a daily oral dose of Tt (5 mg/ kg b. wt.) for eight weeks, from the beginning of the ninth week, they injected i.p. with 2 mg/kg of CdCl4 for 8 days, (Cd group) injected i.p. with 2 mg/kg of CdCl4 for 8 days, (Cd + Tt group) injected i.p. with 2 mg/kg of CdCl4 for eight days, from the ninth day they were given a daily oral dose of Tt (5 mg/ kg b. wt.) for eight weeks. Results revealed that levels of T4 and TAC decreased while levels of TSH and MDA increased in Cd group resulted in follicular cells degeneration, increasing the amount of collagen fibers, and increased positive immunoreactivity of PCNA. Administration of Tt before Cd injection increased levels of T4 and TAC while decreased levels of TSH and MDA. administration of Tt after Cd injection didn't affect T4, TSH, MDA and TAC levels. The pre-treatment with Tt protects the thyroid tissue from those destructive changes by Cd while the post-treatment did not treat them. In conclusion, Tribulus terrestris is highly effective in shielding the thyroid gland from further damaging effects of Cd -induced oxidative stress when utilized as prophylactic antioxidant rather than treatment therapy. https://advetresearch.com/index.php/AVR/article/view/1172Tribulus terrestris, Cadmium, Thyroid, T4, TSH, MDA, TAC, PCNA |
| spellingShingle | Eman Ahmed Negm Alshaimaa A. Alghriany Role of Tribulus terrestris Against Cadmium-induced Toxicity on Thyroid Gland of Adult Male Albino Rats Journal of Advanced Veterinary Research Tribulus terrestris, Cadmium, Thyroid, T4, TSH, MDA, TAC, PCNA |
| title | Role of Tribulus terrestris Against Cadmium-induced Toxicity on Thyroid Gland of Adult Male Albino Rats |
| title_full | Role of Tribulus terrestris Against Cadmium-induced Toxicity on Thyroid Gland of Adult Male Albino Rats |
| title_fullStr | Role of Tribulus terrestris Against Cadmium-induced Toxicity on Thyroid Gland of Adult Male Albino Rats |
| title_full_unstemmed | Role of Tribulus terrestris Against Cadmium-induced Toxicity on Thyroid Gland of Adult Male Albino Rats |
| title_short | Role of Tribulus terrestris Against Cadmium-induced Toxicity on Thyroid Gland of Adult Male Albino Rats |
| title_sort | role of tribulus terrestris against cadmium induced toxicity on thyroid gland of adult male albino rats |
| topic | Tribulus terrestris, Cadmium, Thyroid, T4, TSH, MDA, TAC, PCNA |
| url | https://advetresearch.com/index.php/AVR/article/view/1172 |
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