Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases
Nanotechnology represents an expanding area of research and innovation in almost every field of science, including Medicine, where nanomaterial-based products have been developed for diagnostic and therapeutic applications. Because of their small, nanoscale size, these materials exhibit unique physi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-07-01
|
| Series: | Therapeutic Advances in Urology |
| Online Access: | https://doi.org/10.1177/17562872221109023 |
| _version_ | 1811312303147057152 |
|---|---|
| author | Justin Loloi Mustufa Babar Kelvin P. Davies Sylvia O. Suadicani |
| author_facet | Justin Loloi Mustufa Babar Kelvin P. Davies Sylvia O. Suadicani |
| author_sort | Justin Loloi |
| collection | DOAJ |
| description | Nanotechnology represents an expanding area of research and innovation in almost every field of science, including Medicine, where nanomaterial-based products have been developed for diagnostic and therapeutic applications. Because of their small, nanoscale size, these materials exhibit unique physical and chemical properties that differ from those of each component when considered in bulk. In Nanomedicine, there is an increasing interest in harnessing these unique properties to engineer nanocarriers for the delivery of therapeutic agents. Nano-based drug delivery platforms have many advantages over conventional drug administration routes as this technology allows for local and transdermal applications of therapeutics that can bypass the first-pass metabolism, improves drug efficacy through encapsulation of hydrophobic drugs, and allows for a sustained and controlled release of encapsulated agents. In Urology, nano-based drug delivery platforms have been extensively investigated and implemented for cancer treatment. However, there is also great potential for use of nanotechnology to treat non-oncologic urogenital diseases. We provide an update on research that is paving the way for clinical translation of nanotechnology in the areas of erectile dysfunction (ED), overactive bladder (OAB), interstitial cystitis/bladder pain syndrome (IC/BPS), and catheter-associated urinary tract infections (CAUTIs). Overall, preclinical and clinical studies have proven the utility of nanomaterials both as vehicles for transdermal and intravesical delivery of therapeutic agents and for urinary catheter formulation with antimicrobial agents to treat non-oncologic urogenital diseases. Although clinical translation will be dependent on overcoming regulatory challenges, it is inevitable before there is universal adoption of this technology to treat non-oncologic urogenital diseases. |
| first_indexed | 2024-04-13T10:34:50Z |
| format | Article |
| id | doaj.art-819f595d65c74e659ff7a8dbd22d57fb |
| institution | Directory Open Access Journal |
| issn | 1756-2880 |
| language | English |
| last_indexed | 2024-04-13T10:34:50Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Urology |
| spelling | doaj.art-819f595d65c74e659ff7a8dbd22d57fb2022-12-22T02:50:05ZengSAGE PublishingTherapeutic Advances in Urology1756-28802022-07-011410.1177/17562872221109023Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseasesJustin LoloiMustufa BabarKelvin P. DaviesSylvia O. SuadicaniNanotechnology represents an expanding area of research and innovation in almost every field of science, including Medicine, where nanomaterial-based products have been developed for diagnostic and therapeutic applications. Because of their small, nanoscale size, these materials exhibit unique physical and chemical properties that differ from those of each component when considered in bulk. In Nanomedicine, there is an increasing interest in harnessing these unique properties to engineer nanocarriers for the delivery of therapeutic agents. Nano-based drug delivery platforms have many advantages over conventional drug administration routes as this technology allows for local and transdermal applications of therapeutics that can bypass the first-pass metabolism, improves drug efficacy through encapsulation of hydrophobic drugs, and allows for a sustained and controlled release of encapsulated agents. In Urology, nano-based drug delivery platforms have been extensively investigated and implemented for cancer treatment. However, there is also great potential for use of nanotechnology to treat non-oncologic urogenital diseases. We provide an update on research that is paving the way for clinical translation of nanotechnology in the areas of erectile dysfunction (ED), overactive bladder (OAB), interstitial cystitis/bladder pain syndrome (IC/BPS), and catheter-associated urinary tract infections (CAUTIs). Overall, preclinical and clinical studies have proven the utility of nanomaterials both as vehicles for transdermal and intravesical delivery of therapeutic agents and for urinary catheter formulation with antimicrobial agents to treat non-oncologic urogenital diseases. Although clinical translation will be dependent on overcoming regulatory challenges, it is inevitable before there is universal adoption of this technology to treat non-oncologic urogenital diseases.https://doi.org/10.1177/17562872221109023 |
| spellingShingle | Justin Loloi Mustufa Babar Kelvin P. Davies Sylvia O. Suadicani Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases Therapeutic Advances in Urology |
| title | Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases |
| title_full | Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases |
| title_fullStr | Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases |
| title_full_unstemmed | Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases |
| title_short | Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases |
| title_sort | nanotechnology as a tool to advance research and treatment of non oncologic urogenital diseases |
| url | https://doi.org/10.1177/17562872221109023 |
| work_keys_str_mv | AT justinloloi nanotechnologyasatooltoadvanceresearchandtreatmentofnononcologicurogenitaldiseases AT mustufababar nanotechnologyasatooltoadvanceresearchandtreatmentofnononcologicurogenitaldiseases AT kelvinpdavies nanotechnologyasatooltoadvanceresearchandtreatmentofnononcologicurogenitaldiseases AT sylviaosuadicani nanotechnologyasatooltoadvanceresearchandtreatmentofnononcologicurogenitaldiseases |