Cerebral venous sinus thrombosis after COVID-19 vaccination and congenital deficiency of coagulation factors: Is there a correlation?
In January 2020, SARS-COV-2 infection spread worldwide and was declared “pandemic” by WHO. Because of the high contagiousness of the virus and devastating effects of the epidemic on public health, numerous efforts have been made to develop suitable vaccines to prevent the infection. Among the side e...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-11-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2022.2095166 |
| _version_ | 1797673163106025472 |
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| author | Federica Mele Silvio Tafuri Pasquale Stefanizzi Antonio D Amati Mariagrazia Calvano Mirko Leonardelli Enrica Macorano Stefano Duma Giovanni De Gabriele Francesco Introna Antonio De Donno |
| author_facet | Federica Mele Silvio Tafuri Pasquale Stefanizzi Antonio D Amati Mariagrazia Calvano Mirko Leonardelli Enrica Macorano Stefano Duma Giovanni De Gabriele Francesco Introna Antonio De Donno |
| author_sort | Federica Mele |
| collection | DOAJ |
| description | In January 2020, SARS-COV-2 infection spread worldwide and was declared “pandemic” by WHO. Because of the high contagiousness of the virus and devastating effects of the epidemic on public health, numerous efforts have been made to develop suitable vaccines to prevent the infection. Among the side effects developed by patients who undergone vaccination, there are common symptoms but also more serious reactions such as the thrombosis syndromes. This paper presents two cases of thrombosis temporally associated with live-vectored Covid vaccination similar to vaccine-induced thrombocytopenia (VITT) in patients with inherited thrombophilia (respectively, the deficiency of protein S and a Factor II mutation). The clinical manifestation caused by VITT is characterized by widespread thrombosis especially affecting intracranial venous sinus, which may cause massive bleeding and intracranial hemorrhage. Although this condition is widely described in literature, there is no evident correlation between this side effect and inherited condition of thrombophilia. The authors suggest that the presence of inherited thrombophilia should be better investigated and, if necessary, screened during the anamnestic data collection before the vaccine administration, leading the healthcare professional to choose the appropriate vaccine to the patient. |
| first_indexed | 2024-03-11T21:40:45Z |
| format | Article |
| id | doaj.art-81a47848d23040deba6a1d4842c6a0bc |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:40:45Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-81a47848d23040deba6a1d4842c6a0bc2023-09-26T13:19:08ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2022-11-0118610.1080/21645515.2022.20951662095166Cerebral venous sinus thrombosis after COVID-19 vaccination and congenital deficiency of coagulation factors: Is there a correlation?Federica Mele0Silvio Tafuri1Pasquale Stefanizzi2Antonio D Amati3Mariagrazia Calvano4Mirko Leonardelli5Enrica Macorano6Stefano Duma7Giovanni De Gabriele8Francesco Introna9Antonio De Donno10Aldo Moro University of BariAldo Moro University of BariAldo Moro University of BariAldo Moro University of BariAldo Moro University of BariAldo Moro University of BariAldo Moro University of BariAldo Moro University of BariAldo Moro University of BariAldo Moro University of BariAldo Moro University of BariIn January 2020, SARS-COV-2 infection spread worldwide and was declared “pandemic” by WHO. Because of the high contagiousness of the virus and devastating effects of the epidemic on public health, numerous efforts have been made to develop suitable vaccines to prevent the infection. Among the side effects developed by patients who undergone vaccination, there are common symptoms but also more serious reactions such as the thrombosis syndromes. This paper presents two cases of thrombosis temporally associated with live-vectored Covid vaccination similar to vaccine-induced thrombocytopenia (VITT) in patients with inherited thrombophilia (respectively, the deficiency of protein S and a Factor II mutation). The clinical manifestation caused by VITT is characterized by widespread thrombosis especially affecting intracranial venous sinus, which may cause massive bleeding and intracranial hemorrhage. Although this condition is widely described in literature, there is no evident correlation between this side effect and inherited condition of thrombophilia. The authors suggest that the presence of inherited thrombophilia should be better investigated and, if necessary, screened during the anamnestic data collection before the vaccine administration, leading the healthcare professional to choose the appropriate vaccine to the patient.http://dx.doi.org/10.1080/21645515.2022.2095166covid vaccinesvaccines adverse reactionsvaccine-induced thrombocytopeniainherited thrombophiliaautopsy |
| spellingShingle | Federica Mele Silvio Tafuri Pasquale Stefanizzi Antonio D Amati Mariagrazia Calvano Mirko Leonardelli Enrica Macorano Stefano Duma Giovanni De Gabriele Francesco Introna Antonio De Donno Cerebral venous sinus thrombosis after COVID-19 vaccination and congenital deficiency of coagulation factors: Is there a correlation? Human Vaccines & Immunotherapeutics covid vaccines vaccines adverse reactions vaccine-induced thrombocytopenia inherited thrombophilia autopsy |
| title | Cerebral venous sinus thrombosis after COVID-19 vaccination and congenital deficiency of coagulation factors: Is there a correlation? |
| title_full | Cerebral venous sinus thrombosis after COVID-19 vaccination and congenital deficiency of coagulation factors: Is there a correlation? |
| title_fullStr | Cerebral venous sinus thrombosis after COVID-19 vaccination and congenital deficiency of coagulation factors: Is there a correlation? |
| title_full_unstemmed | Cerebral venous sinus thrombosis after COVID-19 vaccination and congenital deficiency of coagulation factors: Is there a correlation? |
| title_short | Cerebral venous sinus thrombosis after COVID-19 vaccination and congenital deficiency of coagulation factors: Is there a correlation? |
| title_sort | cerebral venous sinus thrombosis after covid 19 vaccination and congenital deficiency of coagulation factors is there a correlation |
| topic | covid vaccines vaccines adverse reactions vaccine-induced thrombocytopenia inherited thrombophilia autopsy |
| url | http://dx.doi.org/10.1080/21645515.2022.2095166 |
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