A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom
Abstract Extracorporeal photopheresis (ECP) is a second‐line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (73.5%). ECP was safe and well tolerated including in...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-07-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.58 |
| _version_ | 1797739967902908416 |
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| author | Aisling M. Flinn Sheba Macheka Mary Slatter Anna‐Maria Ewins Brenda Gibson Sarah Lawson Anna Tailby Giovanna Lucchini Helen New Beki James Arun Alfred Julia Scarisbrick Andrew R Gennery |
| author_facet | Aisling M. Flinn Sheba Macheka Mary Slatter Anna‐Maria Ewins Brenda Gibson Sarah Lawson Anna Tailby Giovanna Lucchini Helen New Beki James Arun Alfred Julia Scarisbrick Andrew R Gennery |
| author_sort | Aisling M. Flinn |
| collection | DOAJ |
| description | Abstract Extracorporeal photopheresis (ECP) is a second‐line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (73.5%). ECP was safe and well tolerated including in low body weight patients. Most patients were on multiple immunosuppressive therapies prior to ECP; 45.9% were able to reduce or stop immunosuppression with treatment. Complete or partial response was reported in almost 60%. This study supports the need to include ECP treatment data to national transplant databases to provide accurate information regarding service provision, patient outcomes, and safety. |
| first_indexed | 2024-03-12T14:05:48Z |
| format | Article |
| id | doaj.art-81a491e2ead84b02aac34f659c1c1c33 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T14:05:48Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-81a491e2ead84b02aac34f659c1c1c332023-08-21T14:10:49ZengWileyeJHaem2688-61462020-07-011129329610.1002/jha2.58A survey of extracorporeal photopheresis treatment in pediatric patients in the United KingdomAisling M. Flinn0Sheba Macheka1Mary Slatter2Anna‐Maria Ewins3Brenda Gibson4Sarah Lawson5Anna Tailby6Giovanna Lucchini7Helen New8Beki James9Arun Alfred10Julia Scarisbrick11Andrew R Gennery12Department of Paediatric Immunology and Haematopoietic Stem Cell Transplantation Great North Children's Hospital Newcastle upon Tyne UKDepartment of Paediatric Immunology and Haematopoietic Stem Cell Transplantation Great North Children's Hospital Newcastle upon Tyne UKDepartment of Paediatric Immunology and Haematopoietic Stem Cell Transplantation Great North Children's Hospital Newcastle upon Tyne UKHaematology/Oncology Department The Royal Hospital for Children Glasgow UKHaematology/Oncology Department The Royal Hospital for Children Glasgow UKDepartment of Haematology Birmingham Children's Hospital Birmingham UKDepartment of Haematology Birmingham Children's Hospital Birmingham UKBMT Department Great Ormond Street Hospital London UKNHS Blood and Transplant London Imperial College London UKRegional Centre for Paediatric Haematology Leeds Children's Hospital Leeds UKDepartment of Photopheresis Rotherham Foundation Trust Rotherham UKDepartment of Dermatology University Hospital Birmingham Birmingham UKDepartment of Paediatric Immunology and Haematopoietic Stem Cell Transplantation Great North Children's Hospital Newcastle upon Tyne UKAbstract Extracorporeal photopheresis (ECP) is a second‐line therapy in acute and chronic GVHD and solid organ transplant rejection. We report ECP use in 98 pediatric patients in seven UK centers from 2010 to 2017, the majority treated for aGVHD (73.5%). ECP was safe and well tolerated including in low body weight patients. Most patients were on multiple immunosuppressive therapies prior to ECP; 45.9% were able to reduce or stop immunosuppression with treatment. Complete or partial response was reported in almost 60%. This study supports the need to include ECP treatment data to national transplant databases to provide accurate information regarding service provision, patient outcomes, and safety.https://doi.org/10.1002/jha2.58extracorporeal photopheresisGVHDimmunosuppressionpediatricstransplantation |
| spellingShingle | Aisling M. Flinn Sheba Macheka Mary Slatter Anna‐Maria Ewins Brenda Gibson Sarah Lawson Anna Tailby Giovanna Lucchini Helen New Beki James Arun Alfred Julia Scarisbrick Andrew R Gennery A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom eJHaem extracorporeal photopheresis GVHD immunosuppression pediatrics transplantation |
| title | A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom |
| title_full | A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom |
| title_fullStr | A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom |
| title_full_unstemmed | A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom |
| title_short | A survey of extracorporeal photopheresis treatment in pediatric patients in the United Kingdom |
| title_sort | survey of extracorporeal photopheresis treatment in pediatric patients in the united kingdom |
| topic | extracorporeal photopheresis GVHD immunosuppression pediatrics transplantation |
| url | https://doi.org/10.1002/jha2.58 |
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