Electrochemical investigations of unexplored anthraquinones and their DNA binding
The redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Association of Physical Chemists (IAPC)
2013-02-01
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| Series: | Journal of Electrochemical Science and Engineering |
| Subjects: | |
| Online Access: | http://www.jese-online.org/Articles/Vol_03/No_1/Pdf/jESE_Vol3_No1_p19-27_2013.pdf |
| _version_ | 1818133517406568448 |
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| author | AFZAL SHAH ABDUR RAU ASAD ULLAH AZEEMA MUNIR RUMANA QURESHI IFTIKHAR AHMAD MUHAMMAD TAHIR SOOMRO ZIA-UR-REHMAN |
| author_facet | AFZAL SHAH ABDUR RAU ASAD ULLAH AZEEMA MUNIR RUMANA QURESHI IFTIKHAR AHMAD MUHAMMAD TAHIR SOOMRO ZIA-UR-REHMAN |
| author_sort | AFZAL SHAH |
| collection | DOAJ |
| description | The redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans on the voltammetric response of anthraquinones. The electrode reaction mechanism was suggested on the basis of cyclic and differential pulse voltammetric results. The effect of DNA on anthraquinones was also probed at physiological pH which could lead to further investigation of possible citotoxic activity in vitro. The results revealed that anthraquinones interact with DNA more strongly than the clinically used anticancer drug, epirubicin. |
| first_indexed | 2024-12-11T08:53:59Z |
| format | Article |
| id | doaj.art-81a4955b34204dcb948492e62252e1e4 |
| institution | Directory Open Access Journal |
| issn | 1847-9286 |
| language | English |
| last_indexed | 2024-12-11T08:53:59Z |
| publishDate | 2013-02-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | Journal of Electrochemical Science and Engineering |
| spelling | doaj.art-81a4955b34204dcb948492e62252e1e42022-12-22T01:13:57ZengInternational Association of Physical Chemists (IAPC)Journal of Electrochemical Science and Engineering1847-92862013-02-0131192710.5599/jese.2012.0026Electrochemical investigations of unexplored anthraquinones and their DNA bindingAFZAL SHAHABDUR RAUASAD ULLAHAZEEMA MUNIRRUMANA QURESHIIFTIKHAR AHMADMUHAMMAD TAHIR SOOMROZIA-UR-REHMANThe redox behaviour of two potential anticancer anthraquinones, 9,10-anthraquinone and 2-chloromethyl-9,10-anthraquinone was investigated in a wide pH range. Cyclic voltammetry based assay was developed for the assessment of the effect of medium, substituents, potential scan rate and number of scans on the voltammetric response of anthraquinones. The electrode reaction mechanism was suggested on the basis of cyclic and differential pulse voltammetric results. The effect of DNA on anthraquinones was also probed at physiological pH which could lead to further investigation of possible citotoxic activity in vitro. The results revealed that anthraquinones interact with DNA more strongly than the clinically used anticancer drug, epirubicin.http://www.jese-online.org/Articles/Vol_03/No_1/Pdf/jESE_Vol3_No1_p19-27_2013.pdfAnthraquinonesredox mechanismvoltammetrybinding constant |
| spellingShingle | AFZAL SHAH ABDUR RAU ASAD ULLAH AZEEMA MUNIR RUMANA QURESHI IFTIKHAR AHMAD MUHAMMAD TAHIR SOOMRO ZIA-UR-REHMAN Electrochemical investigations of unexplored anthraquinones and their DNA binding Journal of Electrochemical Science and Engineering Anthraquinones redox mechanism voltammetry binding constant |
| title | Electrochemical investigations of unexplored anthraquinones and their DNA binding |
| title_full | Electrochemical investigations of unexplored anthraquinones and their DNA binding |
| title_fullStr | Electrochemical investigations of unexplored anthraquinones and their DNA binding |
| title_full_unstemmed | Electrochemical investigations of unexplored anthraquinones and their DNA binding |
| title_short | Electrochemical investigations of unexplored anthraquinones and their DNA binding |
| title_sort | electrochemical investigations of unexplored anthraquinones and their dna binding |
| topic | Anthraquinones redox mechanism voltammetry binding constant |
| url | http://www.jese-online.org/Articles/Vol_03/No_1/Pdf/jESE_Vol3_No1_p19-27_2013.pdf |
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