Sodium butyrate alleviates deoxynivalenol-induced hepatic cholesterol metabolic dysfunction via RORγ-mediated histone acetylation modification in weaning piglets

Sodium butyrate alleviates deoxynivalenol-induced hepatic cholesterol metabolic dysfunction via RORγ-mediated histone acetylation modification in weaning piglets

Abstract Background Cholesterol is an essential component of lipid rafts in cell plasma membrane, which exerts a hepatoprotective role against mycotoxin exposure in pigs, and cholesterol metabolism is vulnerable to epigenetic histone acetylation. Therefore, our present study aimed to investigate whe...

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Bibliographic Details
Main Authors: Qiufang Zong, Huan Qu, Yahui Zhao, Haoyu Liu, Shenglong Wu, Shuai Wang, Wenbin Bao, Demin Cai
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Cholesterol biosynthesis
DON
Histone acetylation
RORγ
Sodium butyrate
Online Access:https://doi.org/10.1186/s40104-022-00793-1

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