VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION
We realized, the definition, of polymorphic variants of genes of folate cycle (C677T, A1298C, A66G) in children with, essential hypertension, having the burdened, and not burdened, hereditary anamnesis of thrombosis. Frequency of the incidence of low functional allele polymorphisms C677T and. A1298C...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2012-04-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/809 |
| _version_ | 1797237695552946176 |
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| author | V. V. Dolgikh S. E. Bolshakova E. S. Philippov M. V. Gomellya |
| author_facet | V. V. Dolgikh S. E. Bolshakova E. S. Philippov M. V. Gomellya |
| author_sort | V. V. Dolgikh |
| collection | DOAJ |
| description | We realized, the definition, of polymorphic variants of genes of folate cycle (C677T, A1298C, A66G) in children with, essential hypertension, having the burdened, and not burdened, hereditary anamnesis of thrombosis. Frequency of the incidence of low functional allele polymorphisms C677T and. A1298C didn't exceed, ubiquitous in the general population, and. in agreement with, those obtained, in other studies, with, an unfavorable genotype GG A66G gene was more frequent than in the population. In all groups of children studied, most often occurred in the carriage of any one of the polymorphic genes, but the combination, of two or even three adverse alleles also met with, relatively high, frequency. No statistically significant differences in the distribution, of genotypes between groups were found. |
| first_indexed | 2024-03-08T12:23:12Z |
| format | Article |
| id | doaj.art-81aa044fcc1b4bd8910e54d2684ac327 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:23:50Z |
| publishDate | 2012-04-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-81aa044fcc1b4bd8910e54d2684ac3272024-03-28T07:49:03ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-04-0102(2)2629755VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSIONV. V. Dolgikh0S. E. Bolshakova1E. S. Philippov2M. V. Gomellya3Scientific Centre of Family Health Problems and Human Reproduction SB RAMS, IrkutskScientific Centre of Family Health Problems and Human Reproduction SB RAMS, IrkutskIrkutsk State Medical UniversityIrkutsk State Medical UniversityWe realized, the definition, of polymorphic variants of genes of folate cycle (C677T, A1298C, A66G) in children with, essential hypertension, having the burdened, and not burdened, hereditary anamnesis of thrombosis. Frequency of the incidence of low functional allele polymorphisms C677T and. A1298C didn't exceed, ubiquitous in the general population, and. in agreement with, those obtained, in other studies, with, an unfavorable genotype GG A66G gene was more frequent than in the population. In all groups of children studied, most often occurred in the carriage of any one of the polymorphic genes, but the combination, of two or even three adverse alleles also met with, relatively high, frequency. No statistically significant differences in the distribution, of genotypes between groups were found.https://www.actabiomedica.ru/jour/article/view/809hypertensiongene polymorphismshomocysteinehyperhomocysteinemia |
| spellingShingle | V. V. Dolgikh S. E. Bolshakova E. S. Philippov M. V. Gomellya VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION Acta Biomedica Scientifica hypertension gene polymorphisms homocysteine hyperhomocysteinemia |
| title | VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION |
| title_full | VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION |
| title_fullStr | VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION |
| title_full_unstemmed | VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION |
| title_short | VARIABILITY OF GENES OF FOLATE CYCLE IN CHILDREN WITH ESSENTIAL ARTERIAL HYPERTENSION |
| title_sort | variability of genes of folate cycle in children with essential arterial hypertension |
| topic | hypertension gene polymorphisms homocysteine hyperhomocysteinemia |
| url | https://www.actabiomedica.ru/jour/article/view/809 |
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