Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses
Abstract Objective To characterize longitudinal changes and correlations between the measures of EQ-5D-Y and generic PedsQL and their associations with clinical changes in children and adolescents with mild-to-moderate chronic kidney disease (CKD). Methods Participants were recruited from January 20...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12955-023-02197-9 |
| _version_ | 1797647202218147840 |
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| author | Chien-Ning Hsu You-Lin Tain Pei-Chen Lu Hsiang-Wen Lin |
| author_facet | Chien-Ning Hsu You-Lin Tain Pei-Chen Lu Hsiang-Wen Lin |
| author_sort | Chien-Ning Hsu |
| collection | DOAJ |
| description | Abstract Objective To characterize longitudinal changes and correlations between the measures of EQ-5D-Y and generic PedsQL and their associations with clinical changes in children and adolescents with mild-to-moderate chronic kidney disease (CKD). Methods Participants were recruited from January 2017 to September 2021 in a medical center in Taiwan. Both instruments were administered in their initial visits and every 6-month subsequent visits. Spearman’s Rho (ρ) was used to assess correlations between the scores of EQ-5D-Y and PedsQL measures in longitudinal changes. Cohen’s effect size (ES) was used to evaluate the changes of scores/subscales over time. In addition, factors associated with longitudinal changes in the score/subscales were explored. Results A total of 121 participants were enrolled, and 83 with ≥ 3 HRQOL measures during the 3.5 years follow-up were assessed their changes of HRQOL measures. The correlations (ρ > 0.3) appeared between the changes in the visual analog scale (VAS) of EQ-5D-Y and emotional and social subscales of PedsQL. ES was small (< 0.5) in the VAS and level-sum-score (LSS) of EQ-5D-Y scores for the clinical changes in comorbidities, while some PedsQL subscales were medium to high (0.5–0.8 or > 0.8). Hypertension, mineral bone disorder/anemia, and hyperuricemia associated with the changes in both HRQOL scores were varied by their various domains. Conclusion Both EQ-5D-Y and PedsQL of HRQOL measures were responsive to worsened childhood CKD-related comorbidities during the follow-up; however, convergent validity between them was limited in some domains. The LSS of EQ-5D-Y showed greater changes than the VAS by comorbidity status; further comparison with utility weight is needed to determine the better performance of EQ-5D-Y. |
| first_indexed | 2024-03-11T15:12:52Z |
| format | Article |
| id | doaj.art-81ae7aaf35a346189e65d046a31d8be4 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-03-11T15:12:52Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-81ae7aaf35a346189e65d046a31d8be42023-10-29T12:37:11ZengBMCHealth and Quality of Life Outcomes1477-75252023-10-0121111310.1186/s12955-023-02197-9Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analysesChien-Ning Hsu0You-Lin Tain1Pei-Chen Lu2Hsiang-Wen Lin3Department of Pharmacy, Kaohsiung Chang Gung Memorial HospitalDivision of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung UniversityDivision of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung UniversitySchool of Pharmacy and Graduate Institute, College of Pharmacy, China Medical UniversityAbstract Objective To characterize longitudinal changes and correlations between the measures of EQ-5D-Y and generic PedsQL and their associations with clinical changes in children and adolescents with mild-to-moderate chronic kidney disease (CKD). Methods Participants were recruited from January 2017 to September 2021 in a medical center in Taiwan. Both instruments were administered in their initial visits and every 6-month subsequent visits. Spearman’s Rho (ρ) was used to assess correlations between the scores of EQ-5D-Y and PedsQL measures in longitudinal changes. Cohen’s effect size (ES) was used to evaluate the changes of scores/subscales over time. In addition, factors associated with longitudinal changes in the score/subscales were explored. Results A total of 121 participants were enrolled, and 83 with ≥ 3 HRQOL measures during the 3.5 years follow-up were assessed their changes of HRQOL measures. The correlations (ρ > 0.3) appeared between the changes in the visual analog scale (VAS) of EQ-5D-Y and emotional and social subscales of PedsQL. ES was small (< 0.5) in the VAS and level-sum-score (LSS) of EQ-5D-Y scores for the clinical changes in comorbidities, while some PedsQL subscales were medium to high (0.5–0.8 or > 0.8). Hypertension, mineral bone disorder/anemia, and hyperuricemia associated with the changes in both HRQOL scores were varied by their various domains. Conclusion Both EQ-5D-Y and PedsQL of HRQOL measures were responsive to worsened childhood CKD-related comorbidities during the follow-up; however, convergent validity between them was limited in some domains. The LSS of EQ-5D-Y showed greater changes than the VAS by comorbidity status; further comparison with utility weight is needed to determine the better performance of EQ-5D-Y.https://doi.org/10.1186/s12955-023-02197-9PediatricsChronic kidney diseaseHealth-related quality of lifeEQ-5D-YPedsQLLongitudinal analysis |
| spellingShingle | Chien-Ning Hsu You-Lin Tain Pei-Chen Lu Hsiang-Wen Lin Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses Health and Quality of Life Outcomes Pediatrics Chronic kidney disease Health-related quality of life EQ-5D-Y PedsQL Longitudinal analysis |
| title | Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses |
| title_full | Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses |
| title_fullStr | Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses |
| title_full_unstemmed | Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses |
| title_short | Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses |
| title_sort | comparisons of eq 5d y and pedsql in pediatric patients with mild to moderate chronic kidney disease in longitudinal analyses |
| topic | Pediatrics Chronic kidney disease Health-related quality of life EQ-5D-Y PedsQL Longitudinal analysis |
| url | https://doi.org/10.1186/s12955-023-02197-9 |
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