Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation
Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many processes required for a successful pregnancy. Over the past decades, increasing evidence gathered from in vitro and in vivo experiments indicate that members of the galectin family specifically bind to bo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.784473/full |
| _version_ | 1819179899037941760 |
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| author | Ellen Menkhorst Ellen Menkhorst Nandor Gabor Than Udo Jeschke Gabriela Barrientos Laszlo Szereday Gabriela Dveksler Sandra M. Blois |
| author_facet | Ellen Menkhorst Ellen Menkhorst Nandor Gabor Than Udo Jeschke Gabriela Barrientos Laszlo Szereday Gabriela Dveksler Sandra M. Blois |
| author_sort | Ellen Menkhorst |
| collection | DOAJ |
| description | Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many processes required for a successful pregnancy. Over the past decades, increasing evidence gathered from in vitro and in vivo experiments indicate that members of the galectin family specifically bind to both intracellular and membrane bound carbohydrate ligands regulating angiogenesis, immune-cell adaptations required to tolerate the fetal semi-allograft and mammalian embryogenesis. Therefore, galectins play important roles in fetal development and placentation contributing to maternal and fetal health. This review discusses the expression and role of galectins during the course of pregnancy, with an emphasis on maternal immune adaptions and galectin-glycan interactions uncovered in the recent years. In addition, we summarize the galectin fingerprints associated with pathological gestation with particular focus on preeclampsia. |
| first_indexed | 2024-12-22T22:05:46Z |
| format | Article |
| id | doaj.art-81b4fc67490142b78a5f2468836a898d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T22:05:46Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-81b4fc67490142b78a5f2468836a898d2022-12-21T18:10:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-12-011210.3389/fimmu.2021.784473784473Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune AdaptationEllen Menkhorst0Ellen Menkhorst1Nandor Gabor Than2Udo Jeschke3Gabriela Barrientos4Laszlo Szereday5Gabriela Dveksler6Sandra M. Blois7Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, AustraliaGynaecological Research Centre, The Women’s Hospital, Melbourne, VIC, AustraliaSystems Biology of Reproduction Research Group, Institute of Enyzmology, Research Centre for Natural Sciences, Budapest, HungaryDepartment of Obstetrics and Gynecology, University Hospital Augsburg, Augsburg, GermanyLaboratorio de Medicina Experimental, Hospital Alemán—Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad Autónoma de Buenos Aires, ArgentinaMedical School, Department of Medical Microbiology and Immunology, University of Pecs, Pecs, HungaryDepartment of Pathology, Uniformed Services University, Bethesda, MD, United StatesDepartment of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyLectin-glycan interactions, in particular those mediated by the galectin family, regulate many processes required for a successful pregnancy. Over the past decades, increasing evidence gathered from in vitro and in vivo experiments indicate that members of the galectin family specifically bind to both intracellular and membrane bound carbohydrate ligands regulating angiogenesis, immune-cell adaptations required to tolerate the fetal semi-allograft and mammalian embryogenesis. Therefore, galectins play important roles in fetal development and placentation contributing to maternal and fetal health. This review discusses the expression and role of galectins during the course of pregnancy, with an emphasis on maternal immune adaptions and galectin-glycan interactions uncovered in the recent years. In addition, we summarize the galectin fingerprints associated with pathological gestation with particular focus on preeclampsia.https://www.frontiersin.org/articles/10.3389/fimmu.2021.784473/fullgalectinspregnancypregnancy specific proteinsglycoimmunologyplacenta |
| spellingShingle | Ellen Menkhorst Ellen Menkhorst Nandor Gabor Than Udo Jeschke Gabriela Barrientos Laszlo Szereday Gabriela Dveksler Sandra M. Blois Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation Frontiers in Immunology galectins pregnancy pregnancy specific proteins glycoimmunology placenta |
| title | Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation |
| title_full | Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation |
| title_fullStr | Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation |
| title_full_unstemmed | Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation |
| title_short | Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation |
| title_sort | medawar s postera galectins emerged as key players during fetal maternal glycoimmune adaptation |
| topic | galectins pregnancy pregnancy specific proteins glycoimmunology placenta |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.784473/full |
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