Review of cystic and solid tumors of the iris
Iris tumors are broadly classified into cystic or solid lesions. The cystic lesions arise from iris pigment epithelium (IPE) or iris stroma. IPE cysts classically remain stable without need for intervention. Iris stromal cyst, especially those in newborns, usually requires therapy of aspiration, pos...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Oman Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ojoonline.org/article.asp?issn=0974-620X;year=2013;volume=6;issue=3;spage=159;epage=164;aulast=Shields |
| _version_ | 1811308832378322944 |
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| author | Carol L Shields Patrick W Shields Janet Manalac Chaisiri Jumroendararasame Jerry A Shields |
| author_facet | Carol L Shields Patrick W Shields Janet Manalac Chaisiri Jumroendararasame Jerry A Shields |
| author_sort | Carol L Shields |
| collection | DOAJ |
| description | Iris tumors are broadly classified into cystic or solid lesions. The cystic lesions arise from iris pigment epithelium (IPE) or iris stroma. IPE cysts classically remain stable without need for intervention. Iris stromal cyst, especially those in newborns, usually requires therapy of aspiration, possibly with alcohol-induced sclerosis, or surgical resection. The solid tumors included melanocytic and nonmelanocytic lesions. The melanocytic iris tumors include freckle, nevus (including melanocytoma), Lisch nodule, and melanoma. Information from a tertiary referral center revealed that transformation of suspicious iris nevus to melanoma occurred in 4% by 10 years and 11% by 20 years. Risk factors for transformation of iris nevus to melanoma can be remembered using the ABCDEF guide as follows: A=age young (<40 years), B=blood (hyphema) in anterior chamber, C=clock hour of mass inferiorly, D=diffuse configuration, E=ectropion, F=feathery margins. The most powerful factors are diffuse growth pattern and hyphema. Tumor seeding into the anterior chamber angle and onto the iris stroma are also important. The nonmelanocytic iris tumors are relatively uncommon and included categories of choristomatous, vascular, fibrous, neural, myogenic, epithelial, xanthomatous, metastatic, lymphoid, leukemic, secondary, and non-neoplastic simulators. Overall, the most common diagnoses in a clinical series include nevus, IPE cyst, and melanoma. In summary, iris tumors comprise a wide spectrum including mostly iris nevus, IPE cyst, and iris melanoma. Risk factors estimating transformation of iris nevus to melanoma can be remembered by the ABCDEF guide. |
| first_indexed | 2024-04-13T09:30:12Z |
| format | Article |
| id | doaj.art-81b5f6fcaab74221bcb3655a9e2133ca |
| institution | Directory Open Access Journal |
| issn | 0974-620X |
| language | English |
| last_indexed | 2024-04-13T09:30:12Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Oman Journal of Ophthalmology |
| spelling | doaj.art-81b5f6fcaab74221bcb3655a9e2133ca2022-12-22T02:52:17ZengWolters Kluwer Medknow PublicationsOman Journal of Ophthalmology0974-620X2013-01-016315916410.4103/0974-620X.122269Review of cystic and solid tumors of the irisCarol L ShieldsPatrick W ShieldsJanet ManalacChaisiri JumroendararasameJerry A ShieldsIris tumors are broadly classified into cystic or solid lesions. The cystic lesions arise from iris pigment epithelium (IPE) or iris stroma. IPE cysts classically remain stable without need for intervention. Iris stromal cyst, especially those in newborns, usually requires therapy of aspiration, possibly with alcohol-induced sclerosis, or surgical resection. The solid tumors included melanocytic and nonmelanocytic lesions. The melanocytic iris tumors include freckle, nevus (including melanocytoma), Lisch nodule, and melanoma. Information from a tertiary referral center revealed that transformation of suspicious iris nevus to melanoma occurred in 4% by 10 years and 11% by 20 years. Risk factors for transformation of iris nevus to melanoma can be remembered using the ABCDEF guide as follows: A=age young (<40 years), B=blood (hyphema) in anterior chamber, C=clock hour of mass inferiorly, D=diffuse configuration, E=ectropion, F=feathery margins. The most powerful factors are diffuse growth pattern and hyphema. Tumor seeding into the anterior chamber angle and onto the iris stroma are also important. The nonmelanocytic iris tumors are relatively uncommon and included categories of choristomatous, vascular, fibrous, neural, myogenic, epithelial, xanthomatous, metastatic, lymphoid, leukemic, secondary, and non-neoplastic simulators. Overall, the most common diagnoses in a clinical series include nevus, IPE cyst, and melanoma. In summary, iris tumors comprise a wide spectrum including mostly iris nevus, IPE cyst, and iris melanoma. Risk factors estimating transformation of iris nevus to melanoma can be remembered by the ABCDEF guide.http://www.ojoonline.org/article.asp?issn=0974-620X;year=2013;volume=6;issue=3;spage=159;epage=164;aulast=ShieldsCysteyeirismelanomametastasisnevustumor |
| spellingShingle | Carol L Shields Patrick W Shields Janet Manalac Chaisiri Jumroendararasame Jerry A Shields Review of cystic and solid tumors of the iris Oman Journal of Ophthalmology Cyst eye iris melanoma metastasis nevus tumor |
| title | Review of cystic and solid tumors of the iris |
| title_full | Review of cystic and solid tumors of the iris |
| title_fullStr | Review of cystic and solid tumors of the iris |
| title_full_unstemmed | Review of cystic and solid tumors of the iris |
| title_short | Review of cystic and solid tumors of the iris |
| title_sort | review of cystic and solid tumors of the iris |
| topic | Cyst eye iris melanoma metastasis nevus tumor |
| url | http://www.ojoonline.org/article.asp?issn=0974-620X;year=2013;volume=6;issue=3;spage=159;epage=164;aulast=Shields |
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