3071 Cell Survival in Corneal Endothelial Dystrophies
OBJECTIVES/SPECIFIC AIMS: Purpose - The goal of this study is to understand how loss of the membrane protein SLC4A11 alters endothelial cell metabolism thereby producing Corneal Endothelial Dystrophy. Studies from our lab indicated that glutamine-dependent mitochondrial dysfunction is one of the out...
Main Authors: | Rajalekshmy Shyam, Diego Ogando, Moonjung Choi, Joseph Bonanno |
---|---|
Format: | Article |
Language: | English |
Published: |
Cambridge University Press
2019-03-01
|
Series: | Journal of Clinical and Translational Science |
Online Access: | https://www.cambridge.org/core/product/identifier/S2059866119000128/type/journal_article |
Similar Items
-
Mitochondrial ROS in Slc4a11 KO Corneal Endothelial Cells Lead to ER Stress
by: Rajalekshmy Shyam, et al.
Published: (2022-04-01) -
Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress
by: Diego G. Ogando, et al.
Published: (2019-09-01) -
Rescue of the Congenital Hereditary Endothelial Dystrophy Mouse Model by Adeno-Associated Virus–Mediated Slc4a11 Replacement
by: Rajalekshmy Shyam, PhD, et al.
Published: (2022-03-01) -
The H<sup>+</sup> Transporter SLC4A11: Roles in Metabolism, Oxidative Stress and Mitochondrial Uncoupling
by: Joseph A. Bonanno, et al.
Published: (2022-01-01) -
Update on the genetics of corneal endothelial dystrophies
by: Chitra Kannabiran, et al.
Published: (2022-01-01)