Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin-1/DCC-UNC5B signal transduction

Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin-1/DCC-UNC5B signal transduction

Background: Cinnamaldehyde (CMD) is a major functional component of Cinnamomum verum and has shown treatment effects against diverse bone diseases. This study aimed to assess the anti-diabetic osteoporosis (DOP) potential of diabetes mellitus (DM) and to explore the underlying mechanism driving the...

Full description

Bibliographic Details
Main Authors:	Songjie Ji, Bingjia Zhao, Yuan Gao, Jun Xie, Huijun Han, Qunli Wu, Dan Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Series:	Frontiers in Pharmacology
Subjects:	cinnamaldehyde diabetic osteoporosis netrin-1 streptozocin TRAP
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1367806/full

Similar Items

Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity
by: Gauri Kulkarni, et al.
Published: (2013-10-01)

Adhesion-clutch between DCC and netrin-1 mediates netrin-1–induced axonal haptotaxis
by: Zhen Qiu, et al.
Published: (2024-02-01)

Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells
by: Melissa Pert, et al.
Published: (2015-01-01)

A Case of Streptozocin Monotherapy for Unresectable Duodenal Neuroendocrine Tumor G2
by: Koji Miyagawa, et al.
Published: (2019-01-01)

A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in Caenorhabditis elegans
by: Snehal S. Mahadik, et al.
Published: (2023-08-01)

The role of netrin G1-netrin-G-ligand-1 in schizophrenia
by: Ayooluwa Gabriel Ibiayo, et al.
Published: (2025-01-01)

Targeting netrin‐1/DCC interaction in diffuse large B‐cell and mantle cell lymphomas
by: Laura Broutier, et al.
Published: (2016-02-01)

Egr-1 increases angiogenesis in cartilage via binding Netrin-1 receptor DCC promoter
by: Jun Sheng, et al.
Published: (2018-05-01)

The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice
by: Vilma Barroca, et al.
Published: (2022-04-01)

UNC-6/Netrin promotes both adhesion and directed growth within a single axon
by: Ev L Nichols, et al.
Published: (2025-03-01)

Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion
by: Ramón Martínez-Mármol, et al.
Published: (2023-09-01)

Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway
by: Jianhao Chen, et al.
Published: (2017-12-01)

The Effects of Methanolic Extract of Prosopis Farcta Seed on Blood Glucose in Streptozocin Induced Diabetic Rats
by: Sahel Heidar Lashkari Heidar Lashkari, et al.
Published: (2017-07-01)

Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study
by: Kumar Inderjeet, et al.
Published: (2022-01-01)

Targeting netrin‐3 in small cell lung cancer and neuroblastoma
by: Shan Jiang, et al.
Published: (2021-03-01)

Relationship of serum netrin-1 levels with breast masses
by: Mehmet Ali Eryilmaz, et al.
Published: (2018-10-01)

Targeting Netrin-1 and -4 as a Novel Diagnostic Parameter and Treatment Option for Diabetic Retinopathy
by: Zewdie KA, et al.
Published: (2020-06-01)

Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis
by: Kainan Zhang, et al.
Published: (2023-12-01)

Wound Healing Activity of the Flavonoid-Enriched Fraction of <i>Selaginella bryopteris</i> Linn. against Streptozocin-Induced Diabetes in Rats
by: Arti Gautam, et al.
Published: (2023-02-01)

Novel and robust treatment of pulmonary hypertension with netrin-1 and netrin-1-derived small peptides
by: Priya Murugesan, et al.
Published: (2022-09-01)

Evaluation of the Effect of Hydroalcoholic Extract of Citrullus colocynthis in Normoglycemic and Streptozocine (STZ) Induced Diabetic Male Rats
by: MR Nikbakht, et al.
Published: (2006-07-01)

Study on the Antidiabetic Effect of Carbon Tetrachloride Extract of Trigonella Foenum Seed in Streptozocin Induced Diabetic Rats
by: Saleh Zahedi Asl, et al.
Published: (2005-12-01)

Mossy Fiber Sprouting in Temporal Lobe Epilepsy: The Impact of Netrin-1, DCC, and Gene Expression Changes
by: Melis Onay, et al.
Published: (2024-12-01)

Evaluation of blood sugar lowering effect of airy organs extract of Cupressus sempervirens L. on streptozocin induced diabetic mice
by: Fatemeh Shaki, et al.
Published: (2019-06-01)

Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway
by: Jian Yu, et al.
Published: (2017-12-01)

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases
by: Kedong Zhu, et al.
Published: (2025-04-01)

Cinnamaldehydes: Synthesis, antibacterial evaluation, and the effect of molecular structure on antibacterial activity
by: Amanda A. Doyle, et al.
Published: (2019-01-01)

Beneficial effects of protocatechuic acid on diabetic retinopathy in streptozocin-induced diabetic rats
by: Ling Wan, et al.
Published: (2023-06-01)

Molecular characterization of the <em>netrin-1 UNC-5</em> receptor in <em>Lucilia sericata</em> larvae
by: Tahereh Karamzadeh, et al.
Published: (2019-08-01)

Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area
by: Marcella M Cline, et al.
Published: (2023-03-01)

Questionable accuracy of four ELISA kits in serum Netrin-1 measurement
by: Cai Minqi, et al.
Published: (2024-08-01)

Netrin-1 promotes epithelium repair in corneal injury
by: Yun Han, et al.
Published: (2020-02-01)

Effects of intra-arterial transplantation of adipose-derived stem cells on the expression of netrin-1 and its receptor DCC in the peri-infarct cortex after experimental stroke
by: Huan Huang, et al.
Published: (2017-10-01)

Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis
by: Lan Huang, et al.
Published: (2022-08-01)

Slowly Digestible Carbohydrate Diet Ameliorates Hyperglycemia and Hyperlipidemia in High-Fat Diet/Streptozocin-Induced Diabetic Mice
by: Yu-Zhong Chen, et al.
Published: (2022-04-01)

Therapeutic effects of topical netrin-4 in a corneal acute inflammatory model
by: Yun Han, et al.
Published: (2015-04-01)

Netrin-1/DCC Signaling Differentially Regulates the Migration of Pax7, Nkx6.1, Irx2, Otp, and Otx2 Cell Populations in the Developing Interpeduncular Nucleus
by: Isabel M. García-Guillén, et al.
Published: (2020-10-01)

Serum netrin and VCAM-1 as biomarker for Egyptian patients with type IΙ diabetes mellitus
by: Maher M. Fadel, et al.
Published: (2021-09-01)

Synthesis, determination, and bio-application in cellular and biomass-bamboo imaging of natural cinnamaldehyde derivatives
by: Jinlai Yang, et al.
Published: (2022-08-01)

Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons
by: Sebastian Poliak, et al.
Published: (2015-12-01)