Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients
COVID-19 caused by SARS-CoV-2 infection is a highly contagious disease affecting both the higher and lower portions of the respiratory tract. This disease reached over 265 million people and has been responsible for over 5.25 million deaths worldwide. Skeletal muscle quality and total mass seem to b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.837719/full |
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| author | Flaydson Clayton Silva Pinto Márcia Fábia Andrade Márcia Fábia Andrade Guilherme Henrique Gatti da Silva Guilherme Henrique Gatti da Silva Jaline Zandonato Faiad Ana Paula Noronha Barrére Renata de Castro Gonçalves Gabriela Salim de Castro Gabriela Salim de Castro Marília Seelaender |
| author_facet | Flaydson Clayton Silva Pinto Márcia Fábia Andrade Márcia Fábia Andrade Guilherme Henrique Gatti da Silva Guilherme Henrique Gatti da Silva Jaline Zandonato Faiad Ana Paula Noronha Barrére Renata de Castro Gonçalves Gabriela Salim de Castro Gabriela Salim de Castro Marília Seelaender |
| author_sort | Flaydson Clayton Silva Pinto |
| collection | DOAJ |
| description | COVID-19 caused by SARS-CoV-2 infection is a highly contagious disease affecting both the higher and lower portions of the respiratory tract. This disease reached over 265 million people and has been responsible for over 5.25 million deaths worldwide. Skeletal muscle quality and total mass seem to be predictive of COVID-19 outcome. This systematic review aimed at providing a critical analysis of the studies published so far reporting on skeletal muscle mass in patients with COVID-19, with the intent of examining the eventual association between muscle status and disease severity. A meta-analysis was performed to evaluate whether skeletal muscle quantity, quality and function were related to disease severity. Systematic reviews and meta-analyses were conducted according to the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions and reported according to the guidelines of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guide. From a total of 1,056 references found, 480 were selected after removing duplicates. Finally, only 7 met the specified inclusion criteria. The results of this meta-analysis showed that skeletal muscle quality, rather than quantity, was associated with COVID-19 severity, as confirmed by lower skeletal muscle density and lower handgrip strength in patients with severe disease. Muscle function assessment can thus be a valuable tool with prognostic value in COVID-19. |
| first_indexed | 2024-04-14T07:18:42Z |
| format | Article |
| id | doaj.art-81b83c5b4d10429f971e5d598cb5e8e0 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-14T07:18:42Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-81b83c5b4d10429f971e5d598cb5e8e02022-12-22T02:06:14ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-04-01910.3389/fnut.2022.837719837719Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 PatientsFlaydson Clayton Silva Pinto0Márcia Fábia Andrade1Márcia Fábia Andrade2Guilherme Henrique Gatti da Silva3Guilherme Henrique Gatti da Silva4Jaline Zandonato Faiad5Ana Paula Noronha Barrére6Renata de Castro Gonçalves7Gabriela Salim de Castro8Gabriela Salim de Castro9Marília Seelaender10Cancer Metabolism Research Group, Department of Surgery, LIM26 HC-USP, University of São Paulo, São Paulo, BrazilCancer Metabolism Research Group, Department of Surgery, LIM26 HC-USP, University of São Paulo, São Paulo, BrazilDepartamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, BrazilCancer Metabolism Research Group, Department of Surgery, LIM26 HC-USP, University of São Paulo, São Paulo, BrazilBiology Department, Brandeis University, Waltham, MA, United StatesCancer Metabolism Research Group, Department of Surgery, LIM26 HC-USP, University of São Paulo, São Paulo, BrazilCancer Metabolism Research Group, Department of Surgery, LIM26 HC-USP, University of São Paulo, São Paulo, BrazilCancer Metabolism Research Group, Department of Surgery, LIM26 HC-USP, University of São Paulo, São Paulo, BrazilCancer Metabolism Research Group, Department of Surgery, LIM26 HC-USP, University of São Paulo, São Paulo, BrazilDepartamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, BrazilCancer Metabolism Research Group, Department of Surgery, LIM26 HC-USP, University of São Paulo, São Paulo, BrazilCOVID-19 caused by SARS-CoV-2 infection is a highly contagious disease affecting both the higher and lower portions of the respiratory tract. This disease reached over 265 million people and has been responsible for over 5.25 million deaths worldwide. Skeletal muscle quality and total mass seem to be predictive of COVID-19 outcome. This systematic review aimed at providing a critical analysis of the studies published so far reporting on skeletal muscle mass in patients with COVID-19, with the intent of examining the eventual association between muscle status and disease severity. A meta-analysis was performed to evaluate whether skeletal muscle quantity, quality and function were related to disease severity. Systematic reviews and meta-analyses were conducted according to the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions and reported according to the guidelines of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guide. From a total of 1,056 references found, 480 were selected after removing duplicates. Finally, only 7 met the specified inclusion criteria. The results of this meta-analysis showed that skeletal muscle quality, rather than quantity, was associated with COVID-19 severity, as confirmed by lower skeletal muscle density and lower handgrip strength in patients with severe disease. Muscle function assessment can thus be a valuable tool with prognostic value in COVID-19.https://www.frontiersin.org/articles/10.3389/fnut.2022.837719/fullCOVID-19sarcopeniaSARS-CoV-2coronavirusdisease outcomeskeletal muscle |
| spellingShingle | Flaydson Clayton Silva Pinto Márcia Fábia Andrade Márcia Fábia Andrade Guilherme Henrique Gatti da Silva Guilherme Henrique Gatti da Silva Jaline Zandonato Faiad Ana Paula Noronha Barrére Renata de Castro Gonçalves Gabriela Salim de Castro Gabriela Salim de Castro Marília Seelaender Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients Frontiers in Nutrition COVID-19 sarcopenia SARS-CoV-2 coronavirus disease outcome skeletal muscle |
| title | Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients |
| title_full | Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients |
| title_fullStr | Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients |
| title_full_unstemmed | Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients |
| title_short | Function Over Mass: A Meta-Analysis on the Importance of Skeletal Muscle Quality in COVID-19 Patients |
| title_sort | function over mass a meta analysis on the importance of skeletal muscle quality in covid 19 patients |
| topic | COVID-19 sarcopenia SARS-CoV-2 coronavirus disease outcome skeletal muscle |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.837719/full |
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