High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81

High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81

Hyperglycemia, lipotoxicity, and insulin resistance are known to increase the secretion of extracellular matrix from cardiac fibroblasts as well as the activation of paracrine signaling from cardiomyocytes, immune cells, and vascular cells, which release fibroblast-activating mediators. However, the...

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Bibliographic Details
Main Authors: Jing Yang, Glenn R. Gourley, Adam Gilbertsen, Chi Chen, Lei Wang, Karen Smith, Marion Namenwirth, Libang Yang
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
smooth muscle cells
phenotype change
glucose
lactate
GPR81
diabetes
Online Access:https://www.mdpi.com/2073-4409/13/3/236

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