| Summary: | Commonly used molecular imaging methods include positron emission tomography (PET), hydrogen magnetic resonance spectroscopy (1H MRS) and imaging (1H MRSI), chemical exchange saturation transfer (CEST), and hyperpolarized 13C MRSI. As a cutting-edge molecular imaging method, deuterium metabolic spectroscopy (DMS) and imaging (DMI) has been recently developed and it distinguishes different tissues according to their specific glycometabolism. Compared with other molecular imaging methods, this promising technique has apparent advantages such as no radioactivity, good stability, and easy to maneuver. In this article, we review the progress of DMS/DMI and discuss its significance, future development, and potential clinical applications.
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