Residues 140–142, 199–200, 222–223, and 262 in the Surface Glycoprotein of Subgroup A Avian Leukosis Virus Are the Key Sites Determining Tva Receptor Binding Affinity and Infectivity

Residues 140–142, 199–200, 222–223, and 262 in the Surface Glycoprotein of Subgroup A Avian Leukosis Virus Are the Key Sites Determining Tva Receptor Binding Affinity and Infectivity

Subgroup A avian leukosis virus (ALV-A) invades cells through gp85-encoded surface glycoprotein (SU) via specifically recognizing the cellular receptor Tva. To identify the key residues of ALV-A SU that determine the Tva binding affinity and infectivity in DF-1 cells, a strategy of substituting corr...

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Bibliographic Details
Main Authors: Jinqun Li, Jian Chen, Xinyi Dong, Canxin Liang, Yanyan Guo, Xiang Chen, Mengyu Huang, Ming Liao, Weisheng Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Microbiology
Subjects:
avian leukosis viruses
Tva
surface glycoprotein
binding affinity
infectivity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.868377/full

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