Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2.
MicroRNAs (miRNAs) have been reported to play a critical role in cancer invasion and metastasis. Our previous study showed that miR-375 frequently downregulated in gastric cancer suppresses cell proliferation by targeting Janus kinase 2 (JAK2). Here, we further found that the expression level of miR...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4108470?pdf=render |
| _version_ | 1819102244451123200 |
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| author | Yanjun Xu Juan Jin Yiman Liu Zhenxia Huang Yujie Deng Tao You Tianhua Zhou Jianmin Si Wei Zhuo |
| author_facet | Yanjun Xu Juan Jin Yiman Liu Zhenxia Huang Yujie Deng Tao You Tianhua Zhou Jianmin Si Wei Zhuo |
| author_sort | Yanjun Xu |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) have been reported to play a critical role in cancer invasion and metastasis. Our previous study showed that miR-375 frequently downregulated in gastric cancer suppresses cell proliferation by targeting Janus kinase 2 (JAK2). Here, we further found that the expression level of miR-375 is significantly decreased in metastatic gastric cancer tissues compared with the non-metastasis controls. Ectopic expression of miR-375 inhibits the migration and invasion of gastric cancer cells partially by targeting JAK2. Furthermore, miR-375 expression is negatively regulated by the metastasis associated transcription factor Snail, which directly binds to the putative promoter of miR-375. Moreover, overexpression of Snail can partially reverse the inhibition of gastric cancer cell migration caused by miR-375. Taken together, these data suggest that miR-375 may be negatively regulated by Snail and involved in gastric cancer cell migration and invasion potentially by targeting JAK2. |
| first_indexed | 2024-12-22T01:31:29Z |
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| id | doaj.art-81baeeacacdd405f8897a12b32cbf8e9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T01:31:29Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-81baeeacacdd405f8897a12b32cbf8e92022-12-21T18:43:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e9951610.1371/journal.pone.0099516Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2.Yanjun XuJuan JinYiman LiuZhenxia HuangYujie DengTao YouTianhua ZhouJianmin SiWei ZhuoMicroRNAs (miRNAs) have been reported to play a critical role in cancer invasion and metastasis. Our previous study showed that miR-375 frequently downregulated in gastric cancer suppresses cell proliferation by targeting Janus kinase 2 (JAK2). Here, we further found that the expression level of miR-375 is significantly decreased in metastatic gastric cancer tissues compared with the non-metastasis controls. Ectopic expression of miR-375 inhibits the migration and invasion of gastric cancer cells partially by targeting JAK2. Furthermore, miR-375 expression is negatively regulated by the metastasis associated transcription factor Snail, which directly binds to the putative promoter of miR-375. Moreover, overexpression of Snail can partially reverse the inhibition of gastric cancer cell migration caused by miR-375. Taken together, these data suggest that miR-375 may be negatively regulated by Snail and involved in gastric cancer cell migration and invasion potentially by targeting JAK2.http://europepmc.org/articles/PMC4108470?pdf=render |
| spellingShingle | Yanjun Xu Juan Jin Yiman Liu Zhenxia Huang Yujie Deng Tao You Tianhua Zhou Jianmin Si Wei Zhuo Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2. PLoS ONE |
| title | Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2. |
| title_full | Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2. |
| title_fullStr | Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2. |
| title_full_unstemmed | Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2. |
| title_short | Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2. |
| title_sort | snail regulated mir 375 inhibits migration and invasion of gastric cancer cells by targeting jak2 |
| url | http://europepmc.org/articles/PMC4108470?pdf=render |
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