ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS
The review presents data on the ubiquitin-proteasome system participation in pathogenesis of gastric cancer. The role of proteasome system in regulation of cell cycle, angiogenesis and tumor metastasis has been shown. The aspects of the participation of ubiquitin-proteasome proteolytic system in the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/276 |
| _version_ | 1797875866954366976 |
|---|---|
| author | E. V. Ivanova I. V. Kondakova О. V. Cheremisina S. G. Afanasyev |
| author_facet | E. V. Ivanova I. V. Kondakova О. V. Cheremisina S. G. Afanasyev |
| author_sort | E. V. Ivanova |
| collection | DOAJ |
| description | The review presents data on the ubiquitin-proteasome system participation in pathogenesis of gastric cancer. The role of proteasome system in regulation of cell cycle, angiogenesis and tumor metastasis has been shown. The aspects of the participation of ubiquitin-proteasome proteolytic system in the pathogenesis of intensive muscle protein degradation in cancer cachexia are analyzed. The role of proteasome system in the development of H. Pylori-induced gastric cancer is discussed. The clinical assessment of selective proteasome inhibitor (bortezomib) is a promising area of research for metastatic gastric cancer. |
| first_indexed | 2024-04-10T01:54:20Z |
| format | Article |
| id | doaj.art-81bcd17f8eb04a16bf9d87839c4ec153 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:54:20Z |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-81bcd17f8eb04a16bf9d87839c4ec1532023-03-13T09:05:48ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01056471276ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESISE. V. Ivanova0I. V. Kondakova1О. V. Cheremisina2S. G. Afanasyev3Томский НИИ онкологииТомский НИИ онкологииТомский НИИ онкологииТомский НИИ онкологииThe review presents data on the ubiquitin-proteasome system participation in pathogenesis of gastric cancer. The role of proteasome system in regulation of cell cycle, angiogenesis and tumor metastasis has been shown. The aspects of the participation of ubiquitin-proteasome proteolytic system in the pathogenesis of intensive muscle protein degradation in cancer cachexia are analyzed. The role of proteasome system in the development of H. Pylori-induced gastric cancer is discussed. The clinical assessment of selective proteasome inhibitor (bortezomib) is a promising area of research for metastatic gastric cancer.https://www.siboncoj.ru/jour/article/view/276протеасомыубиквитинрак желудкаh. pylori |
| spellingShingle | E. V. Ivanova I. V. Kondakova О. V. Cheremisina S. G. Afanasyev ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS Сибирский онкологический журнал протеасомы убиквитин рак желудка h. pylori |
| title | ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS |
| title_full | ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS |
| title_fullStr | ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS |
| title_full_unstemmed | ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS |
| title_short | ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS |
| title_sort | role of ubiquitin proteasome system in gastric cancer pathogenesis |
| topic | протеасомы убиквитин рак желудка h. pylori |
| url | https://www.siboncoj.ru/jour/article/view/276 |
| work_keys_str_mv | AT evivanova roleofubiquitinproteasomesystemingastriccancerpathogenesis AT ivkondakova roleofubiquitinproteasomesystemingastriccancerpathogenesis AT ovcheremisina roleofubiquitinproteasomesystemingastriccancerpathogenesis AT sgafanasyev roleofubiquitinproteasomesystemingastriccancerpathogenesis |