12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes

12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes

IntroductionLipoxygenases (LOXs) have essential roles in stroke, atherosclerosis, diabetes, and hypertension. 12/15-LOX inhibition was shown to reduce infarct size and brain edema in the acute phase of experimental stroke. However, the significance of 12/15-LOX on neuroinflammation, which has an ess...

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Bibliographic Details
Main Authors: Canan Cakir-Aktas, Ebru Bodur, Muge Yemisci, Klaus van Leyen, Hulya Karatas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
12/15-LOX
stroke
ischemia-recanalization
neuroinflammation
inflammasome
NLRP3
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1277268/full

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