Advancement of All-Trans Retinoic Acid Delivery Systems in Dermatological Application
Dermatological conditions, such as acne, photoaging, psoriasis, and wounds, have been treated topically with all-trans retinoic acid (ATRA) for many years owing to its anti-inflammatory activity, comedolytic effect, and ability to increase collagen production. However, common side effects of ATRA kn...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Cosmetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9284/9/6/140 |
| _version_ | 1827641223305756672 |
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| author | Sharifah Shakirah Syed Omar Hazrina Hadi |
| author_facet | Sharifah Shakirah Syed Omar Hazrina Hadi |
| author_sort | Sharifah Shakirah Syed Omar |
| collection | DOAJ |
| description | Dermatological conditions, such as acne, photoaging, psoriasis, and wounds, have been treated topically with all-trans retinoic acid (ATRA) for many years owing to its anti-inflammatory activity, comedolytic effect, and ability to increase collagen production. However, common side effects of ATRA known as the retinoid reaction can occur. These side effects are countered by ATRA encapsulation in solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLCs), and liposomes. Liposomes used to encapsulate ATRA include niosomes, ethosomes, and transfersomes. Side effects involving inflammatory reactions, such as irritation, redness, and erythema, were diminished using these approaches. The use of such carriers enhanced the efficacy of ATRA by enhancing its permeation into skin. These formulations have been compared in terms of improving the activity of ATRA and the ability to relieve the side effects. Further research into different delivery systems for ATRA using various formulations will improve the future of topical ATRA delivery. |
| first_indexed | 2024-03-09T17:10:23Z |
| format | Article |
| id | doaj.art-81bd2e3e41c8417cb0f0c7bfba9c3680 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-09T17:10:23Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-81bd2e3e41c8417cb0f0c7bfba9c36802023-11-24T14:08:50ZengMDPI AGCosmetics2079-92842022-12-019614010.3390/cosmetics9060140Advancement of All-Trans Retinoic Acid Delivery Systems in Dermatological ApplicationSharifah Shakirah Syed Omar0Hazrina Hadi1Dermatopharmaceutics Research Group, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang, MalaysiaDermatopharmaceutics Research Group, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan 25200, Pahang, MalaysiaDermatological conditions, such as acne, photoaging, psoriasis, and wounds, have been treated topically with all-trans retinoic acid (ATRA) for many years owing to its anti-inflammatory activity, comedolytic effect, and ability to increase collagen production. However, common side effects of ATRA known as the retinoid reaction can occur. These side effects are countered by ATRA encapsulation in solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLCs), and liposomes. Liposomes used to encapsulate ATRA include niosomes, ethosomes, and transfersomes. Side effects involving inflammatory reactions, such as irritation, redness, and erythema, were diminished using these approaches. The use of such carriers enhanced the efficacy of ATRA by enhancing its permeation into skin. These formulations have been compared in terms of improving the activity of ATRA and the ability to relieve the side effects. Further research into different delivery systems for ATRA using various formulations will improve the future of topical ATRA delivery.https://www.mdpi.com/2079-9284/9/6/140retinoidsretinoltretinoinliposomesNLCSLN |
| spellingShingle | Sharifah Shakirah Syed Omar Hazrina Hadi Advancement of All-Trans Retinoic Acid Delivery Systems in Dermatological Application Cosmetics retinoids retinol tretinoin liposomes NLC SLN |
| title | Advancement of All-Trans Retinoic Acid Delivery Systems in Dermatological Application |
| title_full | Advancement of All-Trans Retinoic Acid Delivery Systems in Dermatological Application |
| title_fullStr | Advancement of All-Trans Retinoic Acid Delivery Systems in Dermatological Application |
| title_full_unstemmed | Advancement of All-Trans Retinoic Acid Delivery Systems in Dermatological Application |
| title_short | Advancement of All-Trans Retinoic Acid Delivery Systems in Dermatological Application |
| title_sort | advancement of all trans retinoic acid delivery systems in dermatological application |
| topic | retinoids retinol tretinoin liposomes NLC SLN |
| url | https://www.mdpi.com/2079-9284/9/6/140 |
| work_keys_str_mv | AT sharifahshakirahsyedomar advancementofalltransretinoicaciddeliverysystemsindermatologicalapplication AT hazrinahadi advancementofalltransretinoicaciddeliverysystemsindermatologicalapplication |