Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
The preparation of 2', 3'-di-O-hexanoyluridine (2) by a Candida antarctica B lipase-catalysed alcoholysis of 2', 3', 5'-tri-O-hexanoyluridine (1) was optimised using an experimental design. At 25 ºC better experimental conditions allowed an increase in the yield of 2 from 80...
Main Authors: | María A. Zinni, Ernesto M. Aljinovic, Luis E. Iglesias, Adolfo M. Iribarren |
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Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Química
2004-06-01
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Series: | Química Nova |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300022 |
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