Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes
Subchondral bone cysts in horses represent one of the main causes of lameness that can occur in different anatomical locations. The study describes the treatment in regenerative therapy of the intracystic implantation of adipose tissue mesenchymal stromal cells (AMSCs) included in platelet-rich plas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/12/3307 |
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| author | Fernando Canonici Daniele Marcoccia Pamela Bonini Valentina Monteleone Elisa Innocenzi Alessia Zepparoni Annalisa Altigeri Daniela Caciolo Silvia Tofani Paola Ghisellini Cristina Rando Eugenia Pechkova Julietta V. Rau Roberto Eggenhöffner Maria Teresa Scicluna Katia Barbaro |
| author_facet | Fernando Canonici Daniele Marcoccia Pamela Bonini Valentina Monteleone Elisa Innocenzi Alessia Zepparoni Annalisa Altigeri Daniela Caciolo Silvia Tofani Paola Ghisellini Cristina Rando Eugenia Pechkova Julietta V. Rau Roberto Eggenhöffner Maria Teresa Scicluna Katia Barbaro |
| author_sort | Fernando Canonici |
| collection | DOAJ |
| description | Subchondral bone cysts in horses represent one of the main causes of lameness that can occur in different anatomical locations. The study describes the treatment in regenerative therapy of the intracystic implantation of adipose tissue mesenchymal stromal cells (AMSCs) included in platelet-rich plasma (PRP). The ability of AMSCs to differentiate in osteogenic cells was tested in vitro and in vivo. Given the aim to investigate the application of AMSCs in bone defects and orthopedic pathologies in horses, a four-year-old male thoroughbred racing horse that had never raced before was treated for lameness of the left hind leg caused by a cyst of the medial femoral condyle. The horse underwent a new surgery performed with an arthroscopic approach in which the cystic cavity was filled with AMSCs contained in the PRP. Radiographs were taken 3, 5, and 10 months after the surgery to assess the development of newly regenerated bone tissue in the gap left by the cyst. Twelve months after the operation and after six months of regular daily training, the horse did not show any symptoms of lameness and started a racing career. According to the study, the use of AMSCs and PRP suggests promising benefits for treating subchondral bone cysts. |
| first_indexed | 2024-03-08T20:57:47Z |
| format | Article |
| id | doaj.art-81c024b96db2490caa4877abb751d18e |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T20:57:47Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-81c024b96db2490caa4877abb751d18e2023-12-22T13:55:15ZengMDPI AGBiomedicines2227-90592023-12-011112330710.3390/biomedicines11123307Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and OutcomesFernando Canonici0Daniele Marcoccia1Pamela Bonini2Valentina Monteleone3Elisa Innocenzi4Alessia Zepparoni5Annalisa Altigeri6Daniela Caciolo7Silvia Tofani8Paola Ghisellini9Cristina Rando10Eugenia Pechkova11Julietta V. Rau12Roberto Eggenhöffner13Maria Teresa Scicluna14Katia Barbaro15Equine Practice srl, Campagnano, Strada Valle del Baccano 80, 00063 Roma, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyDepartment of Surgical Sciences and Integrated Diagnostics (DISC), Genova University, Corso Europa 30, 16132 Genova, ItalyDepartment of Surgical Sciences and Integrated Diagnostics (DISC), Genova University, Corso Europa 30, 16132 Genova, ItalyConsorzio Interuniversitario INBB, Viale delle Medaglie d’Oro, 305, 00136 Roma, ItalyIstituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, ItalyDepartment of Surgical Sciences and Integrated Diagnostics (DISC), Genova University, Corso Europa 30, 16132 Genova, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalyIstituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, ItalySubchondral bone cysts in horses represent one of the main causes of lameness that can occur in different anatomical locations. The study describes the treatment in regenerative therapy of the intracystic implantation of adipose tissue mesenchymal stromal cells (AMSCs) included in platelet-rich plasma (PRP). The ability of AMSCs to differentiate in osteogenic cells was tested in vitro and in vivo. Given the aim to investigate the application of AMSCs in bone defects and orthopedic pathologies in horses, a four-year-old male thoroughbred racing horse that had never raced before was treated for lameness of the left hind leg caused by a cyst of the medial femoral condyle. The horse underwent a new surgery performed with an arthroscopic approach in which the cystic cavity was filled with AMSCs contained in the PRP. Radiographs were taken 3, 5, and 10 months after the surgery to assess the development of newly regenerated bone tissue in the gap left by the cyst. Twelve months after the operation and after six months of regular daily training, the horse did not show any symptoms of lameness and started a racing career. According to the study, the use of AMSCs and PRP suggests promising benefits for treating subchondral bone cysts.https://www.mdpi.com/2227-9059/11/12/3307subchondral bone cystsregenerative medicinehorseadipose tissue mesenchymal stromal cells (AMSCs) |
| spellingShingle | Fernando Canonici Daniele Marcoccia Pamela Bonini Valentina Monteleone Elisa Innocenzi Alessia Zepparoni Annalisa Altigeri Daniela Caciolo Silvia Tofani Paola Ghisellini Cristina Rando Eugenia Pechkova Julietta V. Rau Roberto Eggenhöffner Maria Teresa Scicluna Katia Barbaro Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes Biomedicines subchondral bone cysts regenerative medicine horse adipose tissue mesenchymal stromal cells (AMSCs) |
| title | Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes |
| title_full | Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes |
| title_fullStr | Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes |
| title_full_unstemmed | Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes |
| title_short | Arthroscopic Treatment of a Subchondral Bone Cyst via Stem Cells Application: A Case Study in Equine Model and Outcomes |
| title_sort | arthroscopic treatment of a subchondral bone cyst via stem cells application a case study in equine model and outcomes |
| topic | subchondral bone cysts regenerative medicine horse adipose tissue mesenchymal stromal cells (AMSCs) |
| url | https://www.mdpi.com/2227-9059/11/12/3307 |
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