Psychiatric Aspects of Obesity: A Narrative Review of Pathophysiology and Psychopathology
In the last decades, obesity has become a major concern for clinical and public health. Despite the variety of available treatments, the outcomes remain—by and large—still unsatisfactory, owing to high rates of nonresponse and relapse. Interestingly, obesity is being associated with a growing surge...
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MDPI AG
2020-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/8/2344 |
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| author | Francesco Weiss Margherita Barbuti Giulia Carignani Alba Calderone Ferruccio Santini Icro Maremmani Giulio Perugi |
| author_facet | Francesco Weiss Margherita Barbuti Giulia Carignani Alba Calderone Ferruccio Santini Icro Maremmani Giulio Perugi |
| author_sort | Francesco Weiss |
| collection | DOAJ |
| description | In the last decades, obesity has become a major concern for clinical and public health. Despite the variety of available treatments, the outcomes remain—by and large—still unsatisfactory, owing to high rates of nonresponse and relapse. Interestingly, obesity is being associated with a growing surge of neuropsychiatric problems, certainly related to the pathogenesis of this condition, and likely to be of great consequence as for its treatment and prognosis. In a neurobiologic direction, a sturdy body of evidence has recently shown that the immune–metabolic–endocrine dyscrasias, notoriously attached to excess body weight/adiposity, affect and impair the morpho-functional integrity of the brain, thus possibly contributing to neuroprogressive/degenerative processes and behavioral deviances. Likewise, in a neuropsychiatric perspective, obesity displays complex associations with mood disorders and affective temperamental dimensions (namely cyclothymia), eating disorders characterized by overeating/binge-eating behaviors, ADHD-related executive dysfunctions, emotional dysregulation and motivational–addictive disturbances. With this review, we attempt to provide the clinician a synoptic, yet exhaustive, tool for a more conscious approach to that subset of this condition, which could be reasonably termed “psychiatric” obesity. |
| first_indexed | 2024-03-10T18:17:01Z |
| format | Article |
| id | doaj.art-81c0b8b5303c4690a97edf7ec75801b9 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:17:01Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-81c0b8b5303c4690a97edf7ec75801b92023-11-20T07:37:58ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0198234410.3390/jcm9082344Psychiatric Aspects of Obesity: A Narrative Review of Pathophysiology and PsychopathologyFrancesco Weiss0Margherita Barbuti1Giulia Carignani2Alba Calderone3Ferruccio Santini4Icro Maremmani5Giulio Perugi62nd Psychiatric Unit, Department of Clinical and Experimental Medicine, Santa Chiara University Hospital, University of Pisa, 56100 Pisa, Italy2nd Psychiatric Unit, Department of Clinical and Experimental Medicine, Santa Chiara University Hospital, University of Pisa, 56100 Pisa, Italy2nd Psychiatric Unit, Department of Clinical and Experimental Medicine, Santa Chiara University Hospital, University of Pisa, 56100 Pisa, ItalyEndocrinological Unit, Department of Clinical and Experimental Medicine, Obesity and Lipodystrophy Research Center, Santa Chiara University Hospital, University of Pisa, 56100 Pisa, ItalyEndocrinological Unit, Department of Clinical and Experimental Medicine, Obesity and Lipodystrophy Research Center, Santa Chiara University Hospital, University of Pisa, 56100 Pisa, Italy2nd Psychiatric Unit, Department of Clinical and Experimental Medicine, Santa Chiara University Hospital, University of Pisa, 56100 Pisa, Italy2nd Psychiatric Unit, Department of Clinical and Experimental Medicine, Santa Chiara University Hospital, University of Pisa, 56100 Pisa, ItalyIn the last decades, obesity has become a major concern for clinical and public health. Despite the variety of available treatments, the outcomes remain—by and large—still unsatisfactory, owing to high rates of nonresponse and relapse. Interestingly, obesity is being associated with a growing surge of neuropsychiatric problems, certainly related to the pathogenesis of this condition, and likely to be of great consequence as for its treatment and prognosis. In a neurobiologic direction, a sturdy body of evidence has recently shown that the immune–metabolic–endocrine dyscrasias, notoriously attached to excess body weight/adiposity, affect and impair the morpho-functional integrity of the brain, thus possibly contributing to neuroprogressive/degenerative processes and behavioral deviances. Likewise, in a neuropsychiatric perspective, obesity displays complex associations with mood disorders and affective temperamental dimensions (namely cyclothymia), eating disorders characterized by overeating/binge-eating behaviors, ADHD-related executive dysfunctions, emotional dysregulation and motivational–addictive disturbances. With this review, we attempt to provide the clinician a synoptic, yet exhaustive, tool for a more conscious approach to that subset of this condition, which could be reasonably termed “psychiatric” obesity.https://www.mdpi.com/2077-0383/9/8/2344psychiatric obesityemotional dysregulationexecutive dysfunctionbipolarityaffective temperamentsfood addiction |
| spellingShingle | Francesco Weiss Margherita Barbuti Giulia Carignani Alba Calderone Ferruccio Santini Icro Maremmani Giulio Perugi Psychiatric Aspects of Obesity: A Narrative Review of Pathophysiology and Psychopathology Journal of Clinical Medicine psychiatric obesity emotional dysregulation executive dysfunction bipolarity affective temperaments food addiction |
| title | Psychiatric Aspects of Obesity: A Narrative Review of Pathophysiology and Psychopathology |
| title_full | Psychiatric Aspects of Obesity: A Narrative Review of Pathophysiology and Psychopathology |
| title_fullStr | Psychiatric Aspects of Obesity: A Narrative Review of Pathophysiology and Psychopathology |
| title_full_unstemmed | Psychiatric Aspects of Obesity: A Narrative Review of Pathophysiology and Psychopathology |
| title_short | Psychiatric Aspects of Obesity: A Narrative Review of Pathophysiology and Psychopathology |
| title_sort | psychiatric aspects of obesity a narrative review of pathophysiology and psychopathology |
| topic | psychiatric obesity emotional dysregulation executive dysfunction bipolarity affective temperaments food addiction |
| url | https://www.mdpi.com/2077-0383/9/8/2344 |
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