Prognostic Value of Tumor Budding for Early Breast Cancer
Background: Tumor budding (TB) is a dynamic process associated with the epithelial–mesenchymal transition and a well-established prognostic biomarker for colorectal cancer. As part of the tumor microenvironment, tumor buds demonstrate increased cell motility and invasiveness. Current evidence demons...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/11/2906 |
| _version_ | 1797460053213577216 |
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| author | Diogo J. Silva Gonçalo Miranda Teresina Amaro Matilde Salgado Alexandra Mesquita |
| author_facet | Diogo J. Silva Gonçalo Miranda Teresina Amaro Matilde Salgado Alexandra Mesquita |
| author_sort | Diogo J. Silva |
| collection | DOAJ |
| description | Background: Tumor budding (TB) is a dynamic process associated with the epithelial–mesenchymal transition and a well-established prognostic biomarker for colorectal cancer. As part of the tumor microenvironment, tumor buds demonstrate increased cell motility and invasiveness. Current evidence demonstrates that high levels of TB correlate with disease progression and worst outcomes across different solid tumors. Our work aims to demonstrate the clinical applicability of TB analysis and its utility as a prognostic factor for patients with early breast cancer (EBC). Methods: Retrospective, single-center, observational study, enrolling patients with EBC diagnosed in a Portuguese hospital between 2014 and 2015. TB classification was performed according to the International Tumor Budding Conference 2016 guidelines. Results: A statistically significant relation was found between higher TB score and aggressive clinicopathological features (angiolymphatic/perineural invasion-<i>p</i> < 0.001; tumor size-<i>p</i> = 0.012; nuclear grading-<i>p</i> < 0.001; and Ki-67 index-<i>p</i> = 0.011), higher number of relapses (<i>p</i> < 0.001), and short disease-free survival (DFS) (<i>p</i> < 0.001). Conclusion: We demonstrate that high TB correlates with shorter DFS and aggressive clinicopathological features used in daily practice to decide on the benefit of chemotherapy for EBC. TB represents a needed prognostic biomarker for EBC, comprising a new factor to be considered in the adjuvant decision-making process by identifying patients at a high risk of relapse and with higher benefit on treatment intensification. Clinical trials incorporating TB are needed to validate its prognostic impact. |
| first_indexed | 2024-03-09T17:00:42Z |
| format | Article |
| id | doaj.art-81c1216b3ae94148a0e88985aab89f80 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:00:42Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-81c1216b3ae94148a0e88985aab89f802023-11-24T14:30:39ZengMDPI AGBiomedicines2227-90592023-10-011111290610.3390/biomedicines11112906Prognostic Value of Tumor Budding for Early Breast CancerDiogo J. Silva0Gonçalo Miranda1Teresina Amaro2Matilde Salgado3Alexandra Mesquita4Hospital Pedro Hispano, Local Health Unity of Matosinhos, 4464-513 Matosinhos, PortugalHospital Pedro Hispano, Local Health Unity of Matosinhos, 4464-513 Matosinhos, PortugalHospital Pedro Hispano, Local Health Unity of Matosinhos, 4464-513 Matosinhos, PortugalHospital Pedro Hispano, Local Health Unity of Matosinhos, 4464-513 Matosinhos, PortugalHospital Pedro Hispano, Local Health Unity of Matosinhos, 4464-513 Matosinhos, PortugalBackground: Tumor budding (TB) is a dynamic process associated with the epithelial–mesenchymal transition and a well-established prognostic biomarker for colorectal cancer. As part of the tumor microenvironment, tumor buds demonstrate increased cell motility and invasiveness. Current evidence demonstrates that high levels of TB correlate with disease progression and worst outcomes across different solid tumors. Our work aims to demonstrate the clinical applicability of TB analysis and its utility as a prognostic factor for patients with early breast cancer (EBC). Methods: Retrospective, single-center, observational study, enrolling patients with EBC diagnosed in a Portuguese hospital between 2014 and 2015. TB classification was performed according to the International Tumor Budding Conference 2016 guidelines. Results: A statistically significant relation was found between higher TB score and aggressive clinicopathological features (angiolymphatic/perineural invasion-<i>p</i> < 0.001; tumor size-<i>p</i> = 0.012; nuclear grading-<i>p</i> < 0.001; and Ki-67 index-<i>p</i> = 0.011), higher number of relapses (<i>p</i> < 0.001), and short disease-free survival (DFS) (<i>p</i> < 0.001). Conclusion: We demonstrate that high TB correlates with shorter DFS and aggressive clinicopathological features used in daily practice to decide on the benefit of chemotherapy for EBC. TB represents a needed prognostic biomarker for EBC, comprising a new factor to be considered in the adjuvant decision-making process by identifying patients at a high risk of relapse and with higher benefit on treatment intensification. Clinical trials incorporating TB are needed to validate its prognostic impact.https://www.mdpi.com/2227-9059/11/11/2906early breast cancertumor buddingbiomarkerepithelial–mesenchymal transition |
| spellingShingle | Diogo J. Silva Gonçalo Miranda Teresina Amaro Matilde Salgado Alexandra Mesquita Prognostic Value of Tumor Budding for Early Breast Cancer Biomedicines early breast cancer tumor budding biomarker epithelial–mesenchymal transition |
| title | Prognostic Value of Tumor Budding for Early Breast Cancer |
| title_full | Prognostic Value of Tumor Budding for Early Breast Cancer |
| title_fullStr | Prognostic Value of Tumor Budding for Early Breast Cancer |
| title_full_unstemmed | Prognostic Value of Tumor Budding for Early Breast Cancer |
| title_short | Prognostic Value of Tumor Budding for Early Breast Cancer |
| title_sort | prognostic value of tumor budding for early breast cancer |
| topic | early breast cancer tumor budding biomarker epithelial–mesenchymal transition |
| url | https://www.mdpi.com/2227-9059/11/11/2906 |
| work_keys_str_mv | AT diogojsilva prognosticvalueoftumorbuddingforearlybreastcancer AT goncalomiranda prognosticvalueoftumorbuddingforearlybreastcancer AT teresinaamaro prognosticvalueoftumorbuddingforearlybreastcancer AT matildesalgado prognosticvalueoftumorbuddingforearlybreastcancer AT alexandramesquita prognosticvalueoftumorbuddingforearlybreastcancer |