| Summary: | Objective: To describe a clinical case of a 46-year-old woman, with overlap of systemic sclerosis and
rheumatoid arthritis who develop panniculitis septal and amyloidosis. Case report: A 46-year-old
female patient with a diagnosis of overlap syndrome (systemic sclerosis and rheumatoid arthritis)
eight years ago evolves with pain and enlargement of the legs . After the hypothesis of panniculitis,
the patient was medicated with antiinflammatory drugs and did not obtain improvement. Subjected
to skin biopsy of the right leg, histopathological findings were compatible with amyloidosis and
discrete panniculitis septal. Final considerations: The presence of panniculitis, which is difficult to
respond to antiinflammatory treatment, should lead to the investigation of infiltrative diseases,
such as amyloidosis. The presence of amyloid deposits in the dermis implies the investigation of
systemic disease
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