Relationships between determinants of adjuvant endocrine therapy adherence in breast cancer
Abstract Background Interventions that promote adjuvant endocrine therapy (AET) adherence are critical to improve breast cancer survival. The development of interventions would benefit from a better understanding of the reasons for adherence and the causal relationships of determinants using theoret...
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12905-018-0522-3 |
| _version_ | 1819039748347396096 |
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| author | Joo Yun Lee Yul Ha Min |
| author_facet | Joo Yun Lee Yul Ha Min |
| author_sort | Joo Yun Lee |
| collection | DOAJ |
| description | Abstract Background Interventions that promote adjuvant endocrine therapy (AET) adherence are critical to improve breast cancer survival. The development of interventions would benefit from a better understanding of the reasons for adherence and the causal relationships of determinants using theoretical or model approaches. The aim of the present study was to identify reasons for AET adherence in breast cancer patients with sequential relationships and inter-relationships. Methods A total of 210 participants with estrogen receptor positive breast cancer who received AET completed a questionnaire assessing demographic/medical, psychological, and endocrine therapy (ET)-specific factors. A descriptive analysis was performed to identify meaningful variables. Selected variables were subjected to hierarchical regression and path analyses. The path model was tested and modified based on the research framework and the results of regression weights and model fit. Results Analysis of sequential effects showed that ET-specific factors contributed the largest proportion of variance (13.4%) to predict AET adherence, followed by psychological factors (4.6%) and demographic/medical factors (3.1%). Analysis of inter-relationships showed that demographic/medical factors such as AET regimen type and cancer stage have direct effects on AET adherence, whereas psychological factors contribute indirectly through the mediating effects of ET-specific factors. Conclusion Assessments and interventions that encompass the patient’s medication beliefs, self-efficacy, and depression are needed to promote AET adherence. |
| first_indexed | 2024-12-21T08:58:08Z |
| format | Article |
| id | doaj.art-81c1d4f81fb74d13871baa70786ba2a4 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-12-21T08:58:08Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-81c1d4f81fb74d13871baa70786ba2a42022-12-21T19:09:31ZengBMCBMC Women's Health1472-68742018-03-011811810.1186/s12905-018-0522-3Relationships between determinants of adjuvant endocrine therapy adherence in breast cancerJoo Yun Lee0Yul Ha Min1College of Nursing, Gachon UniversityCollege of Nursing, Gachon UniversityAbstract Background Interventions that promote adjuvant endocrine therapy (AET) adherence are critical to improve breast cancer survival. The development of interventions would benefit from a better understanding of the reasons for adherence and the causal relationships of determinants using theoretical or model approaches. The aim of the present study was to identify reasons for AET adherence in breast cancer patients with sequential relationships and inter-relationships. Methods A total of 210 participants with estrogen receptor positive breast cancer who received AET completed a questionnaire assessing demographic/medical, psychological, and endocrine therapy (ET)-specific factors. A descriptive analysis was performed to identify meaningful variables. Selected variables were subjected to hierarchical regression and path analyses. The path model was tested and modified based on the research framework and the results of regression weights and model fit. Results Analysis of sequential effects showed that ET-specific factors contributed the largest proportion of variance (13.4%) to predict AET adherence, followed by psychological factors (4.6%) and demographic/medical factors (3.1%). Analysis of inter-relationships showed that demographic/medical factors such as AET regimen type and cancer stage have direct effects on AET adherence, whereas psychological factors contribute indirectly through the mediating effects of ET-specific factors. Conclusion Assessments and interventions that encompass the patient’s medication beliefs, self-efficacy, and depression are needed to promote AET adherence.http://link.springer.com/article/10.1186/s12905-018-0522-3Medication adherenceBreast cancerHormone therapyPredisposing factor |
| spellingShingle | Joo Yun Lee Yul Ha Min Relationships between determinants of adjuvant endocrine therapy adherence in breast cancer BMC Women's Health Medication adherence Breast cancer Hormone therapy Predisposing factor |
| title | Relationships between determinants of adjuvant endocrine therapy adherence in breast cancer |
| title_full | Relationships between determinants of adjuvant endocrine therapy adherence in breast cancer |
| title_fullStr | Relationships between determinants of adjuvant endocrine therapy adherence in breast cancer |
| title_full_unstemmed | Relationships between determinants of adjuvant endocrine therapy adherence in breast cancer |
| title_short | Relationships between determinants of adjuvant endocrine therapy adherence in breast cancer |
| title_sort | relationships between determinants of adjuvant endocrine therapy adherence in breast cancer |
| topic | Medication adherence Breast cancer Hormone therapy Predisposing factor |
| url | http://link.springer.com/article/10.1186/s12905-018-0522-3 |
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