Impact of Nanoclay on the pH-Responsiveness and Biodegradable Behavior of Biopolymer-Based Nanocomposite Hydrogels
This research work deployed free radical polymerization for the development of pH-responsive hybrid nanocomposite hydrogels (NCHs) with the formation of improved interpenetrating networks (IPN). The crosslinked biopolymeric system was composed of (chitosan (CH)/guar gum (GG)/polyol) and a nanofiller...
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MDPI AG
2019-10-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/5/4/44 |
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| author | Arti Vashist Anujit Ghosal Atul Vashist Ajeet Kaushik Y. K. Gupta Madhavan Nair Sharif Ahmad |
| author_facet | Arti Vashist Anujit Ghosal Atul Vashist Ajeet Kaushik Y. K. Gupta Madhavan Nair Sharif Ahmad |
| author_sort | Arti Vashist |
| collection | DOAJ |
| description | This research work deployed free radical polymerization for the development of pH-responsive hybrid nanocomposite hydrogels (NCHs) with the formation of improved interpenetrating networks (IPN). The crosslinked biopolymeric system was composed of (chitosan (CH)/guar gum (GG)/polyol) and a nanofiller (Cloisite 30B). The study was aimed to investigate the role of Cloisite 30B as a nanofiller and linseed oil-derived polyol to induce stable interpenetrating networks in chitosan‒guar gum-based hydrogels. FT-IR analysis confirmed the formation of crosslinked networks with the formation of hydrogen bonds in the synthesized NCHs. Thermogravimetric analysis and differential scanning calorimetry revealed high thermal stability of the NCHs. The hydrolytic and soil burial degradation tests confirmed the biodegradability of the synthesized NCHs. An extraordinarily high swelling capacity in a buffer solution of pH 4.0 and 7.4 demonstrated their pH-responsive behavior. It has been demonstrated that even the minimal addition of polyol to the guar gum-based hydrogels has influenced the stability and characteristic features such as high swelling capacity owing to the formation of interpenetrating networks and the biodegradability of the hydrogels. |
| first_indexed | 2024-12-20T12:32:39Z |
| format | Article |
| id | doaj.art-81c20983be614db38addd6e6f27ff0fd |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-12-20T12:32:39Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-81c20983be614db38addd6e6f27ff0fd2022-12-21T19:40:41ZengMDPI AGGels2310-28612019-10-01544410.3390/gels5040044gels5040044Impact of Nanoclay on the pH-Responsiveness and Biodegradable Behavior of Biopolymer-Based Nanocomposite HydrogelsArti Vashist0Anujit Ghosal1Atul Vashist2Ajeet Kaushik3Y. K. Gupta4Madhavan Nair5Sharif Ahmad6Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, IndiaMaterials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, IndiaDepartment of Biotechnology, All India Institute of Medical Sciences, New Delhi 110029, IndiaCenter for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology & Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USADepartment of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, IndiaCenter for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology & Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USAMaterials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, IndiaThis research work deployed free radical polymerization for the development of pH-responsive hybrid nanocomposite hydrogels (NCHs) with the formation of improved interpenetrating networks (IPN). The crosslinked biopolymeric system was composed of (chitosan (CH)/guar gum (GG)/polyol) and a nanofiller (Cloisite 30B). The study was aimed to investigate the role of Cloisite 30B as a nanofiller and linseed oil-derived polyol to induce stable interpenetrating networks in chitosan‒guar gum-based hydrogels. FT-IR analysis confirmed the formation of crosslinked networks with the formation of hydrogen bonds in the synthesized NCHs. Thermogravimetric analysis and differential scanning calorimetry revealed high thermal stability of the NCHs. The hydrolytic and soil burial degradation tests confirmed the biodegradability of the synthesized NCHs. An extraordinarily high swelling capacity in a buffer solution of pH 4.0 and 7.4 demonstrated their pH-responsive behavior. It has been demonstrated that even the minimal addition of polyol to the guar gum-based hydrogels has influenced the stability and characteristic features such as high swelling capacity owing to the formation of interpenetrating networks and the biodegradability of the hydrogels.https://www.mdpi.com/2310-2861/5/4/44nanocomposite hydrogelscloisite 30bdrug delivery systemchitosanguar gumbiodegradabilityph-responsive |
| spellingShingle | Arti Vashist Anujit Ghosal Atul Vashist Ajeet Kaushik Y. K. Gupta Madhavan Nair Sharif Ahmad Impact of Nanoclay on the pH-Responsiveness and Biodegradable Behavior of Biopolymer-Based Nanocomposite Hydrogels Gels nanocomposite hydrogels cloisite 30b drug delivery system chitosan guar gum biodegradability ph-responsive |
| title | Impact of Nanoclay on the pH-Responsiveness and Biodegradable Behavior of Biopolymer-Based Nanocomposite Hydrogels |
| title_full | Impact of Nanoclay on the pH-Responsiveness and Biodegradable Behavior of Biopolymer-Based Nanocomposite Hydrogels |
| title_fullStr | Impact of Nanoclay on the pH-Responsiveness and Biodegradable Behavior of Biopolymer-Based Nanocomposite Hydrogels |
| title_full_unstemmed | Impact of Nanoclay on the pH-Responsiveness and Biodegradable Behavior of Biopolymer-Based Nanocomposite Hydrogels |
| title_short | Impact of Nanoclay on the pH-Responsiveness and Biodegradable Behavior of Biopolymer-Based Nanocomposite Hydrogels |
| title_sort | impact of nanoclay on the ph responsiveness and biodegradable behavior of biopolymer based nanocomposite hydrogels |
| topic | nanocomposite hydrogels cloisite 30b drug delivery system chitosan guar gum biodegradability ph-responsive |
| url | https://www.mdpi.com/2310-2861/5/4/44 |
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