Small airway dysfunction in idiopathic pulmonary fibrosis
It is generally accepted that the pathophysiology of idiopathic pulmonary fibrosis (IPF) can be attributed to impaired lung interstitium and alveoli, while airway involvement has rarely been reported. In the present study, we aimed to investigate the actual occurrence of IPF comorbid small airway dy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1025814/full |
| _version_ | 1811195215479832576 |
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| author | Chengsheng Yin Chengsheng Yin Huikang Xie Xian He Yuan Zhang Aihong Zhang Huiping Li |
| author_facet | Chengsheng Yin Chengsheng Yin Huikang Xie Xian He Yuan Zhang Aihong Zhang Huiping Li |
| author_sort | Chengsheng Yin |
| collection | DOAJ |
| description | It is generally accepted that the pathophysiology of idiopathic pulmonary fibrosis (IPF) can be attributed to impaired lung interstitium and alveoli, while airway involvement has rarely been reported. In the present study, we aimed to investigate the actual occurrence of IPF comorbid small airway dysfunction (SAD) and its impact on survival. Data from inpatients diagnosed with IPF at Shanghai Pulmonary Hospital (Shanghai, China) from 2011 to 2021 were retrospectively collected and analyzed. Lung function parameters were used to assess SAD. A total of 243 IPF patients were included in this retrospective study, and 84 cases (84/243, 34.57%) were diagnosed with SAD. The lung histopathology showed that all 48 cases undergoing lung transplantation presented various degrees of airway lesions, of which 18 patients (18/48, 37.5%) diagnosed with SAD before lung transplantation had a higher proportion of airway distortion and obliteration. The possible risk factors associated with IPF comorbid SAD were smoking, male, younger age, and high CT fibrosis and emphysema scores. By univariate Fine-Grey regression, the hazard ratio (HR) of IPF comorbid SAD was 1.725 (95% CI 1.071, 2.777, p < 0.05). After adjusting the CTPF model and GAP model, the value of HR was 1.714 (95% CI 1.043, 2.816, p < 0.05) and 1.731 (95% CI 1.074, 2.788, p < 0.05), respectively. These findings suggested that IPF comorbid SAD was an independent risk factor for the mortality of IPF patients. |
| first_indexed | 2024-04-12T00:39:42Z |
| format | Article |
| id | doaj.art-81c2cf3b92d34c0f94a7d645aa92c0fd |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T00:39:42Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-81c2cf3b92d34c0f94a7d645aa92c0fd2022-12-22T03:55:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.10258141025814Small airway dysfunction in idiopathic pulmonary fibrosisChengsheng Yin0Chengsheng Yin1Huikang Xie2Xian He3Yuan Zhang4Aihong Zhang5Huiping Li6Department of Pulmonary and Critical Care Medicine, Yijishan Hospital, The first Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Pathology, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Medical Statistics, Tongji University, School of Medicine, Shanghai, ChinaDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, ChinaIt is generally accepted that the pathophysiology of idiopathic pulmonary fibrosis (IPF) can be attributed to impaired lung interstitium and alveoli, while airway involvement has rarely been reported. In the present study, we aimed to investigate the actual occurrence of IPF comorbid small airway dysfunction (SAD) and its impact on survival. Data from inpatients diagnosed with IPF at Shanghai Pulmonary Hospital (Shanghai, China) from 2011 to 2021 were retrospectively collected and analyzed. Lung function parameters were used to assess SAD. A total of 243 IPF patients were included in this retrospective study, and 84 cases (84/243, 34.57%) were diagnosed with SAD. The lung histopathology showed that all 48 cases undergoing lung transplantation presented various degrees of airway lesions, of which 18 patients (18/48, 37.5%) diagnosed with SAD before lung transplantation had a higher proportion of airway distortion and obliteration. The possible risk factors associated with IPF comorbid SAD were smoking, male, younger age, and high CT fibrosis and emphysema scores. By univariate Fine-Grey regression, the hazard ratio (HR) of IPF comorbid SAD was 1.725 (95% CI 1.071, 2.777, p < 0.05). After adjusting the CTPF model and GAP model, the value of HR was 1.714 (95% CI 1.043, 2.816, p < 0.05) and 1.731 (95% CI 1.074, 2.788, p < 0.05), respectively. These findings suggested that IPF comorbid SAD was an independent risk factor for the mortality of IPF patients.https://www.frontiersin.org/articles/10.3389/fphar.2022.1025814/fullidiopathic pulmonary fibrosissmall airway dysfunctionmortality riskcombined with pulmonary fibrosis and emphysemaIPF combined obstructive ventilator dysfunction |
| spellingShingle | Chengsheng Yin Chengsheng Yin Huikang Xie Xian He Yuan Zhang Aihong Zhang Huiping Li Small airway dysfunction in idiopathic pulmonary fibrosis Frontiers in Pharmacology idiopathic pulmonary fibrosis small airway dysfunction mortality risk combined with pulmonary fibrosis and emphysema IPF combined obstructive ventilator dysfunction |
| title | Small airway dysfunction in idiopathic pulmonary fibrosis |
| title_full | Small airway dysfunction in idiopathic pulmonary fibrosis |
| title_fullStr | Small airway dysfunction in idiopathic pulmonary fibrosis |
| title_full_unstemmed | Small airway dysfunction in idiopathic pulmonary fibrosis |
| title_short | Small airway dysfunction in idiopathic pulmonary fibrosis |
| title_sort | small airway dysfunction in idiopathic pulmonary fibrosis |
| topic | idiopathic pulmonary fibrosis small airway dysfunction mortality risk combined with pulmonary fibrosis and emphysema IPF combined obstructive ventilator dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1025814/full |
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