Protective Effects of Radix Pseudostellariae Extract Against Retinal Laser Injury
Background: This study aimed to analyze the protective effects of a saponin extract from Radix Pseudostellariae (RP) on retinal laser injury based on a retinal photocoagulation model. Methods: Fifty-eight rabbits were randomly divided into three groups: Group A (saponin extract orally), Group B (phy...
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2014-05-01
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| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/362947 |
| _version_ | 1818507894283304960 |
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| author | Guo Rui Wei Wei Wang Yuliang Li Kai Cui Xiaobing Zhu Changle Shen Longshu |
| author_facet | Guo Rui Wei Wei Wang Yuliang Li Kai Cui Xiaobing Zhu Changle Shen Longshu |
| author_sort | Guo Rui |
| collection | DOAJ |
| description | Background: This study aimed to analyze the protective effects of a saponin extract from Radix Pseudostellariae (RP) on retinal laser injury based on a retinal photocoagulation model. Methods: Fifty-eight rabbits were randomly divided into three groups: Group A (saponin extract orally), Group B (physiological saline), and Group C (control). The animals were sacrificed 1 day, 7 days, 14 days, and 30 days after photocoagulation and lesions were evaluated with fundus photography, light microscopy, and electron microscopy. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured, and expression levels of c-fos and Bax genes were also determined. Results: The lesion sizes in Group A were smaller than in Group B. The levels of SOD in Group B were significantly lower than in groups A and C (PConclusion: The saponin extract of RP can inhibit oxidative stress, downregulate the levels of c-fos and Bax gene expression, and inhibit apoptosis in the retina after photocoagulation. |
| first_indexed | 2024-12-10T22:24:26Z |
| format | Article |
| id | doaj.art-81c41b4b399348c8a0a67c2aa4232169 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-10T22:24:26Z |
| publishDate | 2014-05-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-81c41b4b399348c8a0a67c2aa42321692022-12-22T01:31:13ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782014-05-013361643165310.1159/000362947362947Protective Effects of Radix Pseudostellariae Extract Against Retinal Laser InjuryGuo RuiWei WeiWang YuliangLi KaiCui XiaobingZhu ChangleShen LongshuBackground: This study aimed to analyze the protective effects of a saponin extract from Radix Pseudostellariae (RP) on retinal laser injury based on a retinal photocoagulation model. Methods: Fifty-eight rabbits were randomly divided into three groups: Group A (saponin extract orally), Group B (physiological saline), and Group C (control). The animals were sacrificed 1 day, 7 days, 14 days, and 30 days after photocoagulation and lesions were evaluated with fundus photography, light microscopy, and electron microscopy. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured, and expression levels of c-fos and Bax genes were also determined. Results: The lesion sizes in Group A were smaller than in Group B. The levels of SOD in Group B were significantly lower than in groups A and C (PConclusion: The saponin extract of RP can inhibit oxidative stress, downregulate the levels of c-fos and Bax gene expression, and inhibit apoptosis in the retina after photocoagulation.http://www.karger.com/Article/FullText/362947Radix PseudostellariaeFrequency-doubled 532 nm Nd:YAG laserRetina |
| spellingShingle | Guo Rui Wei Wei Wang Yuliang Li Kai Cui Xiaobing Zhu Changle Shen Longshu Protective Effects of Radix Pseudostellariae Extract Against Retinal Laser Injury Cellular Physiology and Biochemistry Radix Pseudostellariae Frequency-doubled 532 nm Nd:YAG laser Retina |
| title | Protective Effects of Radix Pseudostellariae Extract Against Retinal Laser Injury |
| title_full | Protective Effects of Radix Pseudostellariae Extract Against Retinal Laser Injury |
| title_fullStr | Protective Effects of Radix Pseudostellariae Extract Against Retinal Laser Injury |
| title_full_unstemmed | Protective Effects of Radix Pseudostellariae Extract Against Retinal Laser Injury |
| title_short | Protective Effects of Radix Pseudostellariae Extract Against Retinal Laser Injury |
| title_sort | protective effects of radix pseudostellariae extract against retinal laser injury |
| topic | Radix Pseudostellariae Frequency-doubled 532 nm Nd:YAG laser Retina |
| url | http://www.karger.com/Article/FullText/362947 |
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