Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer Survival
<i>Background:</i> Human cytomegalovirus (HCMV) has been detected in tissue samples from patients with glioblastoma but little is known about the systemic immunological response to HCMV in these patients. <i>Objectives:</i> To investigate the presence and clinical significanc...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/59/7/1248 |
| _version_ | 1797588365599571968 |
|---|---|
| author | Inti Peredo-Harvey Jiri Bartek Christer Ericsson Koon-Chu Yaiw Monica Nistér Afsar Rahbar Cecilia Söderberg-Naucler |
| author_facet | Inti Peredo-Harvey Jiri Bartek Christer Ericsson Koon-Chu Yaiw Monica Nistér Afsar Rahbar Cecilia Söderberg-Naucler |
| author_sort | Inti Peredo-Harvey |
| collection | DOAJ |
| description | <i>Background:</i> Human cytomegalovirus (HCMV) has been detected in tissue samples from patients with glioblastoma but little is known about the systemic immunological response to HCMV in these patients. <i>Objectives:</i> To investigate the presence and clinical significance of HCMV antibodies levels in plasma samples obtained from patients with brain tumors. <i>Materials and Methods:</i> HCMV-specific IgG and IgM antibody levels were determined in 59 plasma samples collected from brain tumor patients included in a prospective study and in 114 healthy individuals. We examined if the levels of HCMV specific antibodies varied in patients with different brain tumor diagnoses compared to healthy individuals, and if antibody levels were predictive for survival time. <i>Results</i>: HCMV specific IgG antibodies were detected by ELISA in 80% and 89% of patients with GBM and astrocytoma grades II–III, respectively, in all samples (100%) from patients with secondary GBM and brain metastases, as well as in 80% of healthy donors (<i>n</i> = 114). All plasma samples were negative for HCMV-IgM. Patients with brain metastases who had higher plasma HCMV-IgG titers had longer survival times (<i>p</i> = 0.03). <i>Conclusions</i>: HCMV specific IgG titers were higher among all brain tumor patient groups compared with healthy donors, except for patients with secondary GBM. Higher HCMV specific IgG levels in patients with brain metastases but not in patients with primary brain tumors were associated with prolonged survival time. |
| first_indexed | 2024-03-11T00:50:57Z |
| format | Article |
| id | doaj.art-81c54ba431cd4c2784f9889008fe58e4 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T00:50:57Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-81c54ba431cd4c2784f9889008fe58e42023-11-18T20:23:58ZengMDPI AGMedicina1010-660X1648-91442023-07-01597124810.3390/medicina59071248Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer SurvivalInti Peredo-Harvey0Jiri Bartek1Christer Ericsson2Koon-Chu Yaiw3Monica Nistér4Afsar Rahbar5Cecilia Söderberg-Naucler6Department of Neurosurgery, Karolinska University Hospital, SE-17176 Stockholm, SwedenDepartment of Neurosurgery, Karolinska University Hospital, SE-17176 Stockholm, SwedenCSO iCellate Medical AB, SE-17148 Solna, SwedenDepartment of Medicine Solna, Microbial Pathogenesis Unit, BioClinicum, Karolinska Institutet, SE-17164 Solna, SwedenDepartment of Oncology-Pathology, BioClinicum, Karolinska Institutet, SE-17164 Solna, SwedenDepartment of Medicine Solna, Microbial Pathogenesis Unit, BioClinicum, Karolinska Institutet, SE-17164 Solna, SwedenDepartment of Medicine Solna, Microbial Pathogenesis Unit, BioClinicum, Karolinska Institutet, SE-17164 Solna, Sweden<i>Background:</i> Human cytomegalovirus (HCMV) has been detected in tissue samples from patients with glioblastoma but little is known about the systemic immunological response to HCMV in these patients. <i>Objectives:</i> To investigate the presence and clinical significance of HCMV antibodies levels in plasma samples obtained from patients with brain tumors. <i>Materials and Methods:</i> HCMV-specific IgG and IgM antibody levels were determined in 59 plasma samples collected from brain tumor patients included in a prospective study and in 114 healthy individuals. We examined if the levels of HCMV specific antibodies varied in patients with different brain tumor diagnoses compared to healthy individuals, and if antibody levels were predictive for survival time. <i>Results</i>: HCMV specific IgG antibodies were detected by ELISA in 80% and 89% of patients with GBM and astrocytoma grades II–III, respectively, in all samples (100%) from patients with secondary GBM and brain metastases, as well as in 80% of healthy donors (<i>n</i> = 114). All plasma samples were negative for HCMV-IgM. Patients with brain metastases who had higher plasma HCMV-IgG titers had longer survival times (<i>p</i> = 0.03). <i>Conclusions</i>: HCMV specific IgG titers were higher among all brain tumor patient groups compared with healthy donors, except for patients with secondary GBM. Higher HCMV specific IgG levels in patients with brain metastases but not in patients with primary brain tumors were associated with prolonged survival time.https://www.mdpi.com/1648-9144/59/7/1248human cytomegalovirusbrain tumorsimmunological responseELISA |
| spellingShingle | Inti Peredo-Harvey Jiri Bartek Christer Ericsson Koon-Chu Yaiw Monica Nistér Afsar Rahbar Cecilia Söderberg-Naucler Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer Survival Medicina human cytomegalovirus brain tumors immunological response ELISA |
| title | Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer Survival |
| title_full | Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer Survival |
| title_fullStr | Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer Survival |
| title_full_unstemmed | Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer Survival |
| title_short | Higher Human Cytomegalovirus (HCMV) Specific IgG Antibody Levels in Plasma Samples from Patients with Metastatic Brain Tumors Are Associated with Longer Survival |
| title_sort | higher human cytomegalovirus hcmv specific igg antibody levels in plasma samples from patients with metastatic brain tumors are associated with longer survival |
| topic | human cytomegalovirus brain tumors immunological response ELISA |
| url | https://www.mdpi.com/1648-9144/59/7/1248 |
| work_keys_str_mv | AT intiperedoharvey higherhumancytomegalovirushcmvspecificiggantibodylevelsinplasmasamplesfrompatientswithmetastaticbraintumorsareassociatedwithlongersurvival AT jiribartek higherhumancytomegalovirushcmvspecificiggantibodylevelsinplasmasamplesfrompatientswithmetastaticbraintumorsareassociatedwithlongersurvival AT christerericsson higherhumancytomegalovirushcmvspecificiggantibodylevelsinplasmasamplesfrompatientswithmetastaticbraintumorsareassociatedwithlongersurvival AT koonchuyaiw higherhumancytomegalovirushcmvspecificiggantibodylevelsinplasmasamplesfrompatientswithmetastaticbraintumorsareassociatedwithlongersurvival AT monicanister higherhumancytomegalovirushcmvspecificiggantibodylevelsinplasmasamplesfrompatientswithmetastaticbraintumorsareassociatedwithlongersurvival AT afsarrahbar higherhumancytomegalovirushcmvspecificiggantibodylevelsinplasmasamplesfrompatientswithmetastaticbraintumorsareassociatedwithlongersurvival AT ceciliasoderbergnaucler higherhumancytomegalovirushcmvspecificiggantibodylevelsinplasmasamplesfrompatientswithmetastaticbraintumorsareassociatedwithlongersurvival |